Results 111 to 120 of about 1,535,464 (268)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Case studies of project planning and design for energy conservation
, 1980 Issued as Case study, Project no.
Williams, John Edward
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Aerothermodynamics issues of the DLR hypersonic flight experiment SHEFEX-I
, 2008 Here is presented an overview of the hypersonic experiment on sharp edge concepts, SHEFEX-I. The project, being performed under responsibility of the German Aerospace Center (DLR), is aimed to investigate the behavior and the possibilities of an improved
Eggers, Thino +2 more
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Design of experiment analysis of high velocity oxy-fuel coating of hydroxyapatite [PDF]
, 2009 Due to the flexibility and cost effectiveness the high velocity oxy-fuel (HVOF) thermal spray process has been widely adopted by many industries. Though there are different types of flame spraying processes, the HVOF thermal spray process utilises only ...
Hasan, Shahriar
core
Effect of pressure on the physical properties of magnetorheological fluids [PDF]
Fracture and Structural Integrity, 2013 To date, several applications of magnetorheological (MR) fluids are present in the industrial world, nonetheless system requirements often needs better material properties.
A. Spaggiari, E. Dragoni
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
, 1984 Host Rob Pitt interviews Dr. Mike Booton of the Memorial University Faculty of Engineering and Applied Science about the mechanics of vibration and the importance of vibration in engineering design. Experiments with salt and metal plates demonstrate the
Memorial University of Newfoundland. Educational Television Centre
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source