Results 101 to 110 of about 3,979,734 (303)
Designing an Autonomous Underwater Vehicle hull shape with direct approach
نشریه مهندسی دریا, 2018 Hydrodynamic design of the exterior hull shape is a main step of body shape design. The effective parameters in this process include the length of the nose and tail, the blunt sections of nose and tail as well as the profiles of the nose and the tail. In
Majid Alijani +2 more
doaj
Design and Optimization of Cooling Plate for Battery Module of an Electric Vehicle
Applied Sciences, 2019 With the development of electric vehicles, much attention has been paid to the thermal management of batteries. The liquid cooling has been increasingly used instead of other cooling methods, such as air cooling and phase change material cooling. In this
Ben Ye +2 more
doaj +1 more source
Teaching high frequency words to poor readers using flashcards : its effects on novel word acquisition, skill trasfer to in-text word reading, and passage reading competencies : a thesis in partial fulfillment of the requirements for the degree of Master of Educational Psychology, Massey University, Albany, New Zealand [PDF]
, 2016 Several literacy reports published in the last decade have emphasised the large gap in the reading attainment of children in New Zealand. A common barrier that prevents poor readers to catch up to their peers is difficulty in reading fluency, which is ...
Iqbal, Butul Samera
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
PharmaceuticsBackground/Objectives: The Self-Nanoemulsifying Drug Delivery System (SNEDDS) has been widely applied in oral drug delivery, particularly for poorly water-soluble compounds.
Sani Ega Priani +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
, 2008 Design Of Experiments (DOE) is needed for experiments with real-life systems, and with either deterministic or random simulation models. This contribution discusses the different types of DOE for these three domains, but focusses on random simulation. DOE may have two goals: sensitivity analysis including factor screening and optimization.
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source