Results 101 to 110 of about 167,983,520 (303)

Winter spraying for the apple aphis (040, Agricultural Experiment Bulletin, 1904)

, 1904
18 p., University of Idaho Agricultural Experiment Station, Bulletin No.
Aldrich, John M.
core  

2009 Arizona Agricultural Experiment Station Research Report

, 2010
Complete issue of Arizona Agricultural Experiment Station Research ...

core   +4 more sources

Quality by Design and In Silico Approach in SNEDDS Development: A Comprehensive Formulation Framework

Pharmaceutics
Background/Objectives: The Self-Nanoemulsifying Drug Delivery System (SNEDDS) has been widely applied in oral drug delivery, particularly for poorly water-soluble compounds.
Sani Ega Priani, Taufik Muhammad Fakih, Gofarana Wilar, Anis Yohana Chaerunisaa, Iyan Sopyan   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

QbD-Based Formulation Development of Amiodarone Hydrochloride Tablet

Pharmaceutics
Background/Objectives: We conducted this study to develop a generic amiodarone tablet pharmaceutically equivalent to the reference drug. This development is crucial for securing a stable supply chain for this orphan drug, which currently faces domestic ...
Chae-Won Jeon, Ju-Hyun Yoon, Joo-Eun Kim
doaj   +1 more source

Design of Experiments [PDF]

, 2008
Design Of Experiments (DOE) is needed for experiments with real-life systems, and with either deterministic or random simulation models. This contribution discusses the different types of DOE for these three domains, but focusses on random simulation. DOE may have two goals: sensitivity analysis including factor screening and optimization.
openaire   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Interpretations of design thinking across a large organization

, 2019
Design thinking has a prominent role as established corporations ramp up innovation efforts focusing on user needs. Current literature provides a plethora of definitions for design thinking with variations in tools, methods and cultures.
Björklund, Tua, van der Marel, Floris, Kosmala, Martyna   +2 more
core   +1 more source