Results 81 to 90 of about 3,979,734 (303)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Development of a Versatile Nanostructured Lipid Carrier (NLC) Using Design of Experiments (DoE)—Part II: Incorporation and Stability of Butamben with Different Surfactants

Pharmaceutics
Nanostructured lipid carriers (NLCs) are typically composed of liquid lipids, solid lipids, and surfactants, enabling the encapsulation of lipophilic drugs. Butamben is a Class II anesthetic drug, according to the Biopharmaceutical Classification System (
Ananda P. Matarazzo, Carlos A. Rios, Gabriela Gerônimo, Roberta Ondei, Eneida de Paula, Márcia C. Breitkreitz   +5 more
doaj   +1 more source

Fiber-Optic Auditory Nerve of Ground in the Suburb: For Traffic Flow Monitoring

IEEE Access, 2019
We propose a novel fiber-optic auditory nerve of ground (FANG) in the suburb based on the fiber-optic distributed vibration sensor (DVS). The feasibility and effectiveness of the principle prototype FANG for traffic flow monitoring are proved and ...
Sheng Liang, Xiaoting Zhao, Ruijun Liu, Xiaodong Zhang, Liang Wang, Xinghua Zhang, Yisheng Lv, Fanchao Meng   +7 more
doaj   +1 more source

Efficient design of experiment for exponential regression models [PDF]

In this paper robust and efficient designs are derived for several exponential decay models. These models are widely used in chemistry, pharmacokinetics or microbiology.
Dette, Holger, Martinez Lopez, Ignacio, Ortiz Rodriguez, Isabel M., Pepelyshev, Andrey   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Design and Implementation of Simulation Experiment of Electronic Communication System Based on MATLAB Software

Electrica, 2022
Ying Li , Zhenqiang Zhang, Wenjing Qu , Nabamita Deb, Mohammed Wasim Bhatt   +4 more
doaj   +1 more source

Design, implementation and experiment of a YeSQL Web Crawler

, 2012
We describe a novel, "focusable", scalable, distributed web crawler based on GNU/Linux and PostgreSQL that we designed to be easily extendible and which we have released under a GNU public licence.
Deveaud, Romain, Francony, Jean-Marc, Joulin, Pierre, Para, Françoise, SanJuan-Ibekwe, Eric   +4 more
core   +1 more source

Designing the Search Experience [PDF]

, 2011
This half-day tutorial provides a practical introduction to Human-Centred Design for information search, access and discovery. We present a concise overview of the fundamental concepts and principles of human information-seeking behaviour and show how to apply these in the design of search user experiences.
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Degrees of Sulfonation: Mapping the Reactivity Landscape of Acridine and Acridone

Organics
Although sulfonated acridines and acridones are valuable scaffolds in diagnostics and materials science, to our best knowledge, there is no comprehensive study that addresses how the degree of sulfonation depends on reaction parameters. To fill this gap,
Péter Kisfaludi, Sára Spátay, Péter Huszthy, Ádám Golcs   +3 more
doaj   +1 more source