Results 91 to 100 of about 167,983,520 (303)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Poultry at the Northwest Experiment Farm, University of Minnesota, Crookston, Minn., 1910

, 1909
This archival publication may not reflect current scientific knowledge or recommendations. Current information available from University of Minnesota Agricultural Experiment Station: http://www.maes.umn.edu/Brown, C.
University of Minnesota. Northwest Experiment Farm (Crookston, Minn.), Brown, C. E.   +1 more
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Crop varieties to fit your growing conditions (209, Experiment Bulletin, 1954)

, 1954
12 p., Idaho Agricultural Experiment Station, Bulletin 209, April ...
University of Idaho. College of Agriculture
core  

Designing an Autonomous Underwater Vehicle hull shape with direct approach

نشریه مهندسی دریا, 2018
Hydrodynamic design of the exterior hull shape is a main step of body shape design. The effective parameters in this process include the length of the nose and tail, the blunt sections of nose and tail as well as the profiles of the nose and the tail. In
Majid Alijani, Nowrouz Mohammad Nouri, Marhamat Zeinali   +2 more
doaj  

Design and Optimization of Cooling Plate for Battery Module of an Electric Vehicle

Applied Sciences, 2019
With the development of electric vehicles, much attention has been paid to the thermal management of batteries. The liquid cooling has been increasingly used instead of other cooling methods, such as air cooling and phase change material cooling. In this
Ben Ye, Md Rashedul Haque Rubel, Hongjun Li   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Preliminary of User Interface Design for Picture Archiving and Communication System

, 2013
[[abstract]]In order to gain entry to modern and technology, medical imaging technology not only has to economically storing, and conveniently accessing, images from multiple modalities, but also focus on user’s experience and interaction.
Lin, Wei-Chun Winine;Lee, Yuan-Zone
core  

Optimal development of apoptotic cells-mimicking liposomes targeting macrophages

Journal of Nanobiotechnology
Macrophages are multifunctional innate immune cells that play indispensable roles in homeostasis, tissue repair, and immune regulation. However, dysregulated activation of macrophages is implicated in the pathogenesis of various human disorders, making ...
Li Zhang, Yujiao Li, Xing Liu, Xiaolu He, Jieyu Zhang, Jun Zhou, Youbei Qiao, Hong Wu, Fangfang Sun, Qing Zhou   +9 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source