Results 91 to 100 of about 3,979,734 (303)

Development of headspace solid-phase microextraction method for the analysis of pesticide residues in fruit and vegetable samples using OFAT design

Journal of Applied Sciences and Environmental Management, 2017
A headspace solid-phase microextraction (HS-SPME) method was developed as a preliminary investigation using univariate approach for the analysis of 14 multiclass pesticide residues in fruits and vegetable samples.
Lukman Bola Abdulra’uf, Amudalat Ranti Lawal, Guan Huat Tan   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Exploring silica nanocarriers SBA-15, SBA-16, COK-12, KIT-6 to enhance Dacomitinib solubility using Quality by Design approach

Results in Chemistry
Dacomitinib is a promising targeted first line drug for lung chemotherapy with high survival rate over other drugs, found with solubility issues limiting its therapeutic efficacy. Silica nanocarriers sought to resolve it. Solubility enhancement performed
Sushma Desai, Pooja Mittal
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Design and operation of a cryogenic charge-integrating preamplifier for the MuSun experiment

, 2014
The central detector in the MuSun experiment is a pad-plane time projection ionization chamber that operates without gas amplification in deuterium at 31 K; it is used to measure the rate of the muon capture process $\mu^- + d \rightarrow n + n + \nu_\mu$
Gray, F. E., Gross, E., Gubanich, M., Kammel, P., Kochenda, L., Kravtsov, P., Murray, M. H., Nadtochy, A., Orozco, D., Osofsky, R., Peterson, D., Petrov, G. E., Phillips, J. D., Ryan, R. A., Stroud, J., Trofimov, V., van Wechel, T., Vasilyev, A., Vznuzdaev, M., Wauters, F.   +19 more
core   +1 more source

Controlled Experimentation in Naturalistic Mobile Settings

, 2013
Performing controlled user experiments on small devices in naturalistic mobile settings has always proved to be a difficult undertaking for many Human Factors researchers.
Chen, Tianyi, Harper, Simon, Yesilada, Yeliz   +2 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Optimal development of apoptotic cells-mimicking liposomes targeting macrophages

Journal of Nanobiotechnology
Macrophages are multifunctional innate immune cells that play indispensable roles in homeostasis, tissue repair, and immune regulation. However, dysregulated activation of macrophages is implicated in the pathogenesis of various human disorders, making ...
Li Zhang, Yujiao Li, Xing Liu, Xiaolu He, Jieyu Zhang, Jun Zhou, Youbei Qiao, Hong Wu, Fangfang Sun, Qing Zhou   +9 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source