Results 41 to 50 of about 167,868,153 (289)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Statistical approaches in surface finishing. Part 3. Design-of-experiments

open access: yes, 2019
This paper is the third and final part of a short series of articles aimed towards describing some of the various statistical methods and approaches that have been used in surface finishing.
J. R. Smith (3336732)   +1 more
core   +1 more source

A short history of algebraic statistics [PDF]

open access: yes, 2008
In algebraic statistics, computational techniques from algebraic geometry become tools to address statistical problems. This, in turn, may prompt research in algebraic geometry. The basic ideas at the core of algebraic statistics will be presented. In
Eva Riccomagno, Riccomagno, Eva
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Experiments All the Way:Diagrams of Dialectics between a Design Research program and Experiments

open access: yes, 2013
Experiments take various forms, have various purposes, and generate various knowledge, depending on how and when they are integrated into a design research study. In this paper, as reflective (co-) design researchers/practitioners, we exemplify and argue
Eriksen, Mette Agger,   +3 more
core   +1 more source

Optimization of Direct 2-propanol Fuel Cell Performance Using Statistical Design of Experiments Approach

open access: yesInternational Journal of Electrochemical Science, 2012
Direct alcohol fuel cells have been attracting enormous research interest as power sources for vehicles and portable electronic devices because alcohols are readily available, their storage and transport can be easily handled with the existing fuel ...
Arfat Anis   +2 more
doaj   +1 more source

Optimization of the Microwave Assisted Glycosylamines Synthesis Based on a Statistical Design of Experiments Approach

open access: yesMolecules, 2020
Glycans carry a vast range of functions in nature. Utilizing their properties and functions in form of polymers, coatings or glycan derivatives for various applications makes the synthesis of modified glycans crucial.
Jo Sing Julia Tang   +5 more
doaj   +1 more source

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