Results 101 to 110 of about 2,311,595 (304)
Metallic nanomedicine in cancer immunotherapy
Acta Pharmaceutica Sinica BImmunotherapy has become a pivotal modality in clinical cancer treatment. However, its effectiveness is limited to a small subset of patients due to the low antigenicity, impaired innate response, and various adaptive immune resistance mechanisms of the ...
Shixuan Li +8 more
doaj +1 more source
Frontiers in Microbiology, 2017 Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic infections in immuno-compromised individuals. Due to its multiple resistances toward antibiotics, the development of new drugs is required.
Giuseppe Allegretta +11 more
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Optimization of broaching design [PDF]
, 2007 Broaching is one of the most recognized machining processes that can yield high productivity and high quality when applied properly. One big disadvantage of broaching is that all process parameters, except cutting speed, are built into the broaching ...
Budak, Erhan +4 more
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Stability Analysis of Neural Networks-Based System Identification
Modelling and Simulation in Engineering, 2008 This paper treats some problems related to nonlinear systems identification. A stability analysis neural network model for identifying nonlinear dynamic systems is presented.
Talel Korkobi +2 more
doaj +1 more source
The Sizing and Optimization Language (SOL): A computer language to improve the user/optimizer interface [PDF]
The nonlinear mathematical programming method (formal optimization) has had many applications in engineering design. A figure illustrates the use of optimization techniques in the design process. The design process begins with the design problem, such as
Lucas, S. H., Scotti, S. J.
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pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Structural Optimization in automotive design [PDF]
Although mathematical structural optimization has been an active research area for twenty years, there has been relatively little penetration into the design process.
Bennett, J. A., Botkin, M. E.
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Insight into High-quality Aerodynamic Design Spaces through Multi-objective Optimization [PDF]
, 2008 An approach to support the computational aerodynamic design process is presented and demonstrated through the application of a novel multi-objective variant of the Tabu Search optimization algorithm for continuous problems to the aerodynamic design ...
Clarkson, P. J. +5 more
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