Results 101 to 110 of about 903,165 (318)

Multi-Objective Numerical Optimization Applied to Aircraft Design

, 2008
Aircraft design is a very complex process because several disciplines are involved at the same time: aerodynamics, structures, performances, propulsion, costs. From this point of view, the real aircraft is a compromise between several requirements, often
Grasso, Francesco
core  

Multi-objective design optimization for high-lift aircraft configurations supported by surrogate modeling [PDF]

, 2013
Nowadays, the competition among airlines seriously depend upon the saving operating costs, with the premise that not to degrade its services quality.
Li, Daxin
core  

Metallic nanomedicine in cancer immunotherapy

Acta Pharmaceutica Sinica B
Immunotherapy has become a pivotal modality in clinical cancer treatment. However, its effectiveness is limited to a small subset of patients due to the low antigenicity, impaired innate response, and various adaptive immune resistance mechanisms of the ...
Shixuan Li, Xiaohu Wang, Huiyun Han, Shuting Xiang, Mingxi Li, Guangyu Long, Yanming Xia, Qiang Zhang, Suxin Li   +8 more
doaj   +1 more source

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

Frontiers in Microbiology, 2017
Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic infections in immuno-compromised individuals. Due to its multiple resistances toward antibiotics, the development of new drugs is required.
Giuseppe Allegretta, Christine K. Maurer, Jens Eberhard, Damien Maura, Damien Maura, Damien Maura, Rolf W. Hartmann, Rolf W. Hartmann, Laurence Rahme, Laurence Rahme, Laurence Rahme, Martin Empting   +11 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Short Course on Optimization Technology and Applications in High Frequency and Microwave Circuit Design

, 1994
Course notes and advertisement for a Short Course given at the Department of Electromagnetic Theory and Engineering, Duisburg University, Duisburg, Germany. The course was delivered by John W. Bandler and S.H. Chen on October 4 and 5, 1994.
Bandler, John W., Chen, S.H., Optimization Systems Associates   +2 more
core  

Insight into high-quality aerodynamic design spaces through multi-objective optimization [PDF]

, 2008
An approach to support the computational aerodynamic design process is presented and demonstrated through the application of a novel multi-objective variant of the Tabu Search optimization algorithm for continuous problems to the aerodynamic design ...
Kipouros, Timoleon, Parks, Geoff, Jaeggi, Daniel, Savill, Mark A., Clarkson, P. J., Dawes, Bill   +5 more
core  

Design of High Temperature Ti–Al–Cr–V Alloys for Maximum Thermodynamic Stability Using Self-Organizing Maps

Metals, 2019
Data generated for the Ti−Al−Cr−V system of metallic alloys from our previous publication, where the composition of 102 alloys were computationally Pareto optimized with the objective of simultaneously maximizing the Young’s ...
Rajesh Jha, George S. Dulikravich
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Structural design optimization [PDF]

, 2007
Guest Editorial, Special Issue on Structural Design Optimization, Advances in Structural Engineering, An International Journal, 2007, Vol.
Liang, Qing Quan
core