Results 81 to 90 of about 903,165 (318)

Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib‐Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency

Advanced Science
Overcoming acquired resistance to Osimertinib remains a critical challenge in treating NSCLC. This research indicates that Osimertinib‐resistant cells exhibit a strong dependence on glutamine metabolism.
Jiali Huang, Xiankang Zhang, Hui Zhang, Yu Li, Huidan Huang, Zhiyu Li, Zhixia Qiu, Hongxi Wu, Dechun Huang, Xi Xu, Jinlei Bian   +10 more
doaj   +1 more source

Optimal Design of Cams

Multibody System Dynamics, 2002
The paper presents a methodology which is based on a constrained optimization algorithm where the constraints are the maximum valve lift and timing. The objective is to maximize the time integral of valve area opened to gas flow. Once the optimal lift is known, the cam profile can be developed using inverse kinematic analysis. Finally, the authors give
Cardona, Alberto, Lens, Elisabeth, Nigro, Norberto Marcelo   +2 more
openaire   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Optimization techniques with knowledge based control in ship concept design

, 1990
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.An integrated computational approach to Ship Concept Design using optimization techniques and a knowledge base to control the optimization process has been ...
Schachter, Richard David, Schachter, R.D
core  

Approximated computation of belief functions for robust design optimization

, 2012
This paper presents some ideas to reduce the computational cost of evidence-based robust design optimization. Evidence Theory crystallizes both the aleatory and epistemic uncertainties in the design parameters, providing two quantitative measures, Belief
Massimilano Vasile, Vasile, Massimiliano, Edmondo Minisci, Minisci, Edmondo, Wijnands, Quirien, Quirien Wijnands   +5 more
core   +1 more source

A novel shape optimization method using knot insertion algorithm in B-spline and its application to transonic airfoil design [PDF]

, 2011
A new method using the cubic B-spline curves with nominal uniform knot set to parameterize the geometry is proposed to deal with shape optimization problems.
Xu, B., Sherar, P. A., Zhong, B., Thompson, Christopher P.   +3 more
core   +1 more source

A CIA Triad-Based Taxonomy of Prompt Attacks on Large Language Models

Future Internet
The rapid proliferation of Large Language Models (LLMs) across industries such as healthcare, finance, and legal services has revolutionized modern applications.
Nicholas Jones, Md Whaiduzzaman, Tony Jan, Amr Adel, Ammar Alazab, Afnan Alkreisat   +5 more
doaj   +1 more source

Discovery of New Ti-Based Alloys Aimed at Avoiding/Minimizing Formation of α” and ω-Phase Using CALPHAD and Artificial Intelligence

Metals, 2020
In this work, we studied a Ti-Nb-Zr-Sn system for exploring novel composition and temperatures that will be helpful in maximizing the stability of β phase while minimizing the formation of α” and ω-phase. The Ti-Nb-Zr-Sn system is free of toxic elements.
Rajesh Jha, George S. Dulikravich
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source