Results 61 to 70 of about 903,165 (318)
Acta Pharmaceutica Sinica B, 2021 Lung cancers are the leading cause of cancer deaths worldwide and pose a grave threat to human life and health. Non-small cell lung cancer (NSCLC) is the most frequent malignancy occupying 80% of all lung cancer subtypes. Except for other mutations (e.g.,
Cuicui Li +9 more
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Redox Biology, 2019 The Keap1-Nrf2-ARE pathway regulates the constitutive and inducible transcription of various genes that encode detoxification enzymes, antioxidant proteins and anti-inflammatory proteins and has pivotal roles in the defence against cellular oxidative ...
Meng-Chen Lu +6 more
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Testing approaches for global optimization of space trajectories [PDF]
, 2008 In this paper the procedures to test global search algorithms applied to space trajectory design problems are discussed. Furthermore, a number of performance indexes that can be used to evaluate the effectiveness of the tested algorithms are presented.
Vasile, M. +7 more
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Multidisciplinary design optimization of UAV airframes
, 2006 If one considers the problem of converting an aircraft mission profile into an airframe design from an optimization theory perspective, it becomes obvious that the search problem comes with all the trimmings.
Andy Keane +3 more
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Multiobjective optimization for multiproduct batch plant design under economic and environmental considerations [PDF]
, 2006 This work deals with the multicriteria cost–environment design of multiproduct batch plants, where the design variables are the size of the equipment items as well as the operating conditions.
Dietz, Adrian +3 more
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Robotics: Science and Systems I, 2005 Synthesis of robots may be decomposed into two processes: {\em structural synthesis} (determine the general arrangement of the mechanical structure such as the type and number of joints and the way they will be connected) and {\em dimensional synthesis} (determine the length of the links, the axis and location of the joints, the necessary maximal joint
openaire +2 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Computer-Aided Conceptual Design Through TRIZ-based Manipulation of Topological Optimizations [PDF]
, 2009 Organised by: Cranfield UniversityIn a recent project the authors proposed the adoption of Optimization Systems [1] as a bridging element between Computer-Aided Innovation (CAI) and PLM to identify geometrical contradictions [2], a particular case of ...
Cascini, G. +3 more
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