Results 61 to 70 of about 11,290,757 (236)

Multi-Objective Numerical Optimization Applied to Aircraft Design [PDF]

, 2008
Aircraft design is a very complex process because several disciplines are involved at the same time: aerodynamics, structures, performances, propulsion, costs. From this point of view, the real aircraft is a compromise between several requirements, often
Grasso, Francesco
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Addressing Clinical Limitations of Glutaminase Inhibitors: Novel Strategies for Osimertinib‐Resistant Lung Cancer by Exploiting Glutamine Metabolic Dependency

Advanced Science
Overcoming acquired resistance to Osimertinib remains a critical challenge in treating NSCLC. This research indicates that Osimertinib‐resistant cells exhibit a strong dependence on glutamine metabolism.
Jiali Huang, Xiankang Zhang, Hui Zhang, Yu Li, Huidan Huang, Zhiyu Li, Zhixia Qiu, Hongxi Wu, Dechun Huang, Xi Xu, Jinlei Bian   +10 more
doaj   +1 more source

Development of Novel Nrf2/ARE Inducers Bearing Pyrazino[2,1-a]isoquinolin Scaffold with Potent In Vitro Efficacy and Enhanced Physicochemical Properties

Molecules, 2017
Pyrazino[2,1-a]isoquinolin analogues were reported as potent activators of Nrf2/ARE signaling both in vitro and in vivo by our group. In this study, we simplified the ring system to investigate the functions of various parts of the pyrazino[2,1-a ...
Hongbin Dai, Qiong Jiao, Tian Liu, Qidong You, Zhengyu Jiang   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Identification of Inhibitors of the Anti-Infective Target DXS Using Dynamic Combinatorial Chemistry

Proceedings, 2019
Antibiotic resistance is one of the biggest threats to humankind [1,2]. [...]
Ravindra P. Jumde, Alaa Alhayek, Robin M. Gierse, Anna K. H. Hirsch   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

On testing global optimization algorithms for space trajectory design [PDF]

, 2008
In this paper we discuss the procedures to test a global search algorithm applied to a space trajectory design problem. Then, we present some performance indexes that can be used to evaluate the effectiveness of global optimization algorithms.
Marco Locatelli, Vasile, M., Vasile, Massimiliano, Edmondo Minisci, VASILE M, MINISCI E, Locatelli, M, Minisci, Edmondo, Minisci, E., Locatelli, Marco, Massimiliano Vasile   +10 more
core   +2 more sources

Combinatorial Route Optimization Using Near-Training-Free Foundation Models

Eng
Combinatorial Route Optimization (CRO) problems, such as the Vehicle Routing Problem (VRP) or the Travelling Salesman Problem (TSP), are commonly seen in scheduling, logistics, and transportation.
Nguyen Gia Hien Vu, Yifan Tang, Rey Lim, Yifan Yang, Hang Ma, Ke Wang, G. Gary Wang   +6 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source