Results 51 to 60 of about 598,406 (269)

Advances in the structures, mechanisms and targeting of molecular chaperones

Signal Transduction and Targeted Therapy
Molecular chaperones, a class of complex client regulatory systems, play significant roles in the prevention of protein misfolding and abnormal aggregation, the modulation of protein homeostasis, and the protection of cells from damage under constantly ...
Jinying Gu, Yanyi He, Chenxi He, Qiuyue Zhang, Qifei Huang, Shangjun Bai, Ruoning Wang, Qidong You, Lei Wang   +8 more
doaj   +1 more source

Optimal Design of Cams

Multibody System Dynamics, 2002
The paper presents a methodology which is based on a constrained optimization algorithm where the constraints are the maximum valve lift and timing. The objective is to maximize the time integral of valve area opened to gas flow. Once the optimal lift is known, the cam profile can be developed using inverse kinematic analysis. Finally, the authors give
Cardona, Alberto, Lens, Elisabeth, Nigro, Norberto Marcelo   +2 more
openaire   +3 more sources

ASSIST: Refinement of a Benefits Navigator Intervention Among Low‐Income Pediatric Oncology Families

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Children with cancer living in poverty experience worse survival and quality of life. Interventions connecting low‐income families to benefits (e.g., Supplemental Nutrition Assistance Program [SNAP] improve health outcomes; yet nearly 50% of SNAP‐eligible pediatric oncology families are unenrolled.
Puja J. Umaretiya, Selena Murcia Mendez, Jennifer Kellett, Sarah Wright, Marisel Ponton, Robin T. Higashi, Rahela Aziz‐Bose, Colleen A. Kelly, Ayesha Zia, Joanne Wolfe, Sandi L. Pruitt, Kira Bona   +11 more
wiley   +1 more source

Optimal design of robots

Robotics: Science and Systems I, 2005
Synthesis of robots may be decomposed into two processes: {\em structural synthesis} (determine the general arrangement of the mechanical structure such as the type and number of joints and the way they will be connected) and {\em dimensional synthesis} (determine the length of the links, the axis and location of the joints, the necessary maximal joint
openaire   +2 more sources

Bridging the Gap in Neuroblastoma Care: Consensus‐Based Statements With Recommendations for Improved Patient and Caregiver Experiences

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neuroblastoma's complex, heterogeneous biology poses significant diagnostic and therapeutic challenges, often requiring caregivers to absorb complex information and participate in time‐sensitive decisions. However, caregivers often feel unprepared to evaluate options.
Vickie Buenger, Joseph Bauer, Jennifer Diamond, Maggie Fader, Shae Hansen, Jacqueline M. Kraveka, Johanna Schoen, Amber Shearer, Dena Sherwood   +8 more
wiley   +1 more source

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

Redox Biology, 2019
The Keap1-Nrf2-ARE pathway regulates the constitutive and inducible transcription of various genes that encode detoxification enzymes, antioxidant proteins and anti-inflammatory proteins and has pivotal roles in the defence against cellular oxidative ...
Meng-Chen Lu, Jing Zhao, Yu-Ting Liu, Tian Liu, Meng-Min Tao, Qi-Dong You, Zheng-Yu Jiang   +6 more
doaj   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas, Jakob Q. Weiss, Kellee N. Parker, Cathy Lee‐Miller   +3 more
wiley   +1 more source

Novel Resveratrol Derivatives as Dual PDE4 Inhibitors and Free Radical Scavengers: Rational Design, Synthesis, and Biological Evaluation

Antioxidants
A novel class of resveratrol derivatives as dual PDE4 (Phosphodiesterase 4) inhibitors and free radical scavengers for the treatment of COPD (chronic obstructive pulmonary disease) was developed in this study.
Youzhi Wang, Huizhen Shen, Ying Liang, Guoqing Yang, Botao Zhang, Yunbao Zhi, Jinxin Wang   +6 more
doaj   +1 more source

Optimal Platform Design

CoRR, 2014
There is some overlap between this paper and the paper "Optimal Mechanism Design and Money Burning," which appeared in the STOC 2008 conference and as arXiv:0804.2097. However, the focus of this paper is different, with some of our earlier results omitted and several new results ...
Jason D. Hartline, Tim Roughgarden
openaire   +2 more sources