Results 31 to 40 of about 2,311,595 (304)

A-optimal design matrices

open access: yesDiscrete Mathematics, 1984
The tools in search of A-optimal designs are listed and the authors derive A-optimal chemical balance weighing designs (that is, \(N\times n\) matrices with elements 1, -1 and 0) for \(N\geq 7\), \(n\leq 6\).
Chi Song Wong, Joseph C. Masaro
openaire   +1 more source

Quantization Design for Distributed Optimization [PDF]

open access: yes, 2015
We consider the problem of solving a distributed optimization problem using a distributed computing platform, where the communication in the network is limited: each node can only communicate with its neighbours and the channel has a limited data-rate. A
Jones, Colin N.   +2 more
core   +3 more sources

‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents

open access: yesMolecules, 2017
DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of the Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro, but poor efficacy in vivo due to its poor
Xiang Li   +4 more
doaj   +1 more source

A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications

open access: yesEuropean Journal of Medicinal Chemistry Reports, 2022
Cycloastragenol (CAG) is a sapogenin of Astragaloside IV (AG-IV), isolated from the dried roots of legumes Astragalus mongolica or Astragalus membranaceus.
Mengting He   +7 more
doaj   +1 more source

Flow structures and wall parameters on rotating riblet disks and their effects on drag reduction

open access: yesAlexandria Engineering Journal, 2022
The demand of energy saving and loss mitigation in modern industry gives rise to drag reduction techniques such as micro groove/riblet ever since the last century.
Tong Liang   +3 more
doaj   +1 more source

A constrained multi-objective surrogate-based optimization algorithm [PDF]

open access: yes, 2014
Surrogate models or metamodels are widely used in the realm of engineering for design optimization to minimize the number of computationally expensive simulations.
Couckuyt, Ivo   +3 more
core   +1 more source

Development of a variance prioritized multiresponse robust design framework for quality improvement [PDF]

open access: yes, 2009
Robust design is a well-known quality improvement method that focuses on building quality into the design of products and services. Yet, most well established robust design models only consider a single performance measure and their prioritization ...
Antony, Jiju   +2 more
core   +1 more source

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges   +12 more
wiley   +1 more source

BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression

open access: yesScientific Reports, 2021
Poly (ADP-ribose) polymerase (PARP) inhibitors offer a significant clinical benefit for triple-negative breast cancers (TNBCs) with BRCA1/2 mutation. However, the narrow clinical indication limits the development of PARP inhibitors.
Yu Li   +5 more
doaj   +1 more source

Nonlinear Matroid Optimization and Experimental Design [PDF]

open access: yes, 2007
We study the problem of optimizing nonlinear objective functions over matroids presented by oracles or explicitly. Such functions can be interpreted as the balancing of multi-criteria optimization. We provide a combinatorial polynomial time algorithm for
Eva Riccomagno   +7 more
core   +7 more sources

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