Results 11 to 20 of about 903,165 (318)

Optimal Crowdfunding Design [PDF]

SSRN Electronic Journal, 2014
We characterize optimal reward-based crowdfunding where production is contingent on an aggregate funding threshold. Crowdfunding adapts project implementation to demand (market-testing) and its multiple prices enhance rent-extraction via pivotality, even for large crowds, indeed arbitrarily large if tastes are correlated.
Matthew Ellman, Sjaak Hurkens
openaire   +8 more sources

Optimal Technology Design

SSRN Electronic Journal, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Garrett, Daniel F., Georgiadis, George, Smolin, Alex, Szentes, Balazs   +3 more
openaire   +4 more sources

Removal of Tetracycline in Sewage and Dairy Products with High-Stable MOF

Molecules, 2020
Serious environmental and human health problems caused by the abuse of antibiotics have attracted worldwide concern. Recently, metal−organic frameworks (MOFs) with high porosity have drawn wide attention for their effects in the adsorption and ...
Kan Li, Jing-jing Li, Ni Zhao, Ying Ma, Bin Di   +4 more
doaj   +1 more source

Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein–Protein Interactions: An Update

Antioxidants, 2022
The oxidative stress response pathway is one of the hotspots of current pharmaceutical research. Many proteins involved in these pathways work through protein–protein interactions (PPIs).
Xuexuan Wu, Qiuyue Zhang, Yuqi Guo, Hengheng Zhang, Xiaoke Guo, Qidong You, Lei Wang   +6 more
doaj   +1 more source

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

Molecules, 2021
Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction is currently the focus in the field of cancer immunotherapy, and so far, several monoclonal antibodies (mAbs) have achieved encouraging outcomes in cancer ...
Hongbo Zhang, Yu Xia, Chunqiu Yu, Huijie Du, Jinchang Liu, Hui Li, Shihui Huang, Qihua Zhu, Yungen Xu, Yi Zou   +9 more
doaj   +1 more source

Optimization design in single wagon-wheel fuel grain of hybrid rocket motor

FirePhysChem, 2021
The grain design of hybrid rocket motor is a design of proper fuel grain geometry and flow adjustment scheme based on the total impulse, thrust, chamber pressure, length and outer diameter of combustion chamber.
Wei Tianfang, Cai Guobiao, Tian Hui, Zhu Hao, Zhang Yuanjun, Li Xintong   +5 more
doaj   +1 more source

On Optimal Rerandomization Designs [PDF]

Journal of the Royal Statistical Society Series B: Statistical Methodology, 2021
AbstractBlocking is commonly used in randomized experiments to increase efficiency of estimation. A generalization of blocking removes allocations with imbalance in covariate distributions between treated and control units, and then randomizes within the remaining set of allocations with balance.
Johansson, Per, Rubin, Donald B., Schultzberg, Mårten   +2 more
openaire   +2 more sources

Forward or Backward: Lessons Learned from Small Molecule Drugs Approved by FDA from 2012 to 2022

Molecules, 2023
At every juncture in history, the design and identification of new drugs pose significant challenges. To gain valuable insights for future drug development, we conducted a detailed analysis of New Molecular Entitiy (NME) approved by the Food and Drug ...
Mingxiao Gu, Sudan Sun, Qidong You, Lei Wang   +3 more
doaj   +1 more source

Multidisciplinary design optimization framework for the pre design stage [PDF]

, 2010
Presented is a novel framework for performing flexible computational design studies at preliminary design stage. It incorporates a workflow management device (WMD) and a number of advanced numerical treatments, including multi-objective optimization ...
Balachandran, Libish Kalathil, Padulo, Mattia, Paolo Fantini, Nunez, Marco, Marin Guenov, Libish Balachandran, Guenov, Marin D., Maginot, Jeremy, Marco Nunez, Mattia Padulo, Jeremy Maginot, Fantini, Paolo   +11 more
core   +1 more source

A Framework for Situated Design Optimization [PDF]

, 2006
This paper presents a framework for situated design optimization that expands the traditional view of design optimization. It is based on the notion of interaction providing the potential for modifications of various aspects of the optimization process ...
John S. Gero, U. Kannengiesser, Udo Kannengiesser, J.S. Gero   +3 more
core   +1 more source