Results 11 to 20 of about 598,406 (269)

Data driven analysis of social capital in Farmer Producer Companies

open access: yesHeliyon, 2023
The Farmer Producer Company (FPC), a subset of the Farmer Producer Organization (FPO), is an important institutional form designed to organize farmer groups towards better coordinated farming and marketing.
Aishwarya Jayaraman   +3 more
doaj   +1 more source

Optimal Technology Design

open access: yesSSRN Electronic Journal, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Garrett, Daniel F.   +3 more
openaire   +4 more sources

Removal of Tetracycline in Sewage and Dairy Products with High-Stable MOF

open access: yesMolecules, 2020
Serious environmental and human health problems caused by the abuse of antibiotics have attracted worldwide concern. Recently, metal−organic frameworks (MOFs) with high porosity have drawn wide attention for their effects in the adsorption and ...
Kan Li   +4 more
doaj   +1 more source

Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein–Protein Interactions: An Update

open access: yesAntioxidants, 2022
The oxidative stress response pathway is one of the hotspots of current pharmaceutical research. Many proteins involved in these pathways work through protein–protein interactions (PPIs).
Xuexuan Wu   +6 more
doaj   +1 more source

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

open access: yesMolecules, 2021
Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction is currently the focus in the field of cancer immunotherapy, and so far, several monoclonal antibodies (mAbs) have achieved encouraging outcomes in cancer ...
Hongbo Zhang   +9 more
doaj   +1 more source

Optimal Monitoring Design [PDF]

open access: yesEconometrica, 2020
This paper considers a Principal–Agent model with hidden action in which the Principal can monitor the Agent by acquiring independent signals conditional on effort at a constant marginal cost. The Principal aims to implement a target effort level at minimal cost. The main result of the paper is that the optimal information‐acquisition strategy is a two‐
Georgiadis, George, Szentes, Balazs
openaire   +1 more source

Optimization design in single wagon-wheel fuel grain of hybrid rocket motor

open access: yesFirePhysChem, 2021
The grain design of hybrid rocket motor is a design of proper fuel grain geometry and flow adjustment scheme based on the total impulse, thrust, chamber pressure, length and outer diameter of combustion chamber.
Wei Tianfang   +5 more
doaj   +1 more source

On Optimal Rerandomization Designs [PDF]

open access: yesJournal of the Royal Statistical Society Series B: Statistical Methodology, 2021
AbstractBlocking is commonly used in randomized experiments to increase efficiency of estimation. A generalization of blocking removes allocations with imbalance in covariate distributions between treated and control units, and then randomizes within the remaining set of allocations with balance.
Johansson, Per   +2 more
openaire   +2 more sources

Forward or Backward: Lessons Learned from Small Molecule Drugs Approved by FDA from 2012 to 2022

open access: yesMolecules, 2023
At every juncture in history, the design and identification of new drugs pose significant challenges. To gain valuable insights for future drug development, we conducted a detailed analysis of New Molecular Entitiy (NME) approved by the Food and Drug ...
Mingxiao Gu   +3 more
doaj   +1 more source

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope

open access: yesActa Pharmaceutica Sinica B, 2022
The proteolysis targeting chimeras (PROTACs) technology has been rapidly developed since its birth in 2001, attracting rapidly growing attention of scientific institutes and pharmaceutical companies.
Sinan Ma   +10 more
doaj   +1 more source

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