Results 11 to 20 of about 11,290,757 (236)

Optimization techniques with knowledge based control in ship concept design [PDF]

open access: yes, 1990
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.An integrated computational approach to Ship Concept Design using optimization techniques and a knowledge base to control the optimization process has been ...
Schachter, Richard David
core   +7 more sources

Learning-based ship design optimization approach [PDF]

open access: yes, 2012
With the development of computer applications in ship design, optimization, as a powerful approach, has been widely used in the design and analysis process.
Turan, Osman, Cui, Hao, Sayer, Philip
core   +4 more sources

Design optimization of permanent magnet actuators. [PDF]

open access: yes, 1992
This study describes the design optimization of permanent actuators, of both rotary and linear topologies. Parameter scanning, constrained single and multi-criterion optimization techniques are developed, with due emphasis on the efficient ...
Widdowson, G P
core   +6 more sources

Removal of Tetracycline in Sewage and Dairy Products with High-Stable MOF

open access: yesMolecules, 2020
Serious environmental and human health problems caused by the abuse of antibiotics have attracted worldwide concern. Recently, metal−organic frameworks (MOFs) with high porosity have drawn wide attention for their effects in the adsorption and ...
Kan Li   +4 more
doaj   +1 more source

Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein–Protein Interactions: An Update

open access: yesAntioxidants, 2022
The oxidative stress response pathway is one of the hotspots of current pharmaceutical research. Many proteins involved in these pathways work through protein–protein interactions (PPIs).
Xuexuan Wu   +6 more
doaj   +1 more source

Computer-Aided Conceptual Design Through TRIZ-based Manipulation of Topological Optimizations [PDF]

open access: yes, 2009
Organised by: Cranfield UniversityIn a recent project the authors proposed the adoption of Optimization Systems [1] as a bridging element between Computer-Aided Innovation (CAI) and PLM to identify geometrical contradictions [2], a particular case of ...
Cascini, G.   +3 more
core   +7 more sources

Integrated qualitativeness in design by multi-objective optimization and interactive evolutionary computation. [PDF]

open access: yes, 2005
- The concept of qualitativeness in design is an important one, and needs to be incorporated in the optimization process for a number of reasons outlined in this paper.
Tiwari, Ashutosh   +2 more
core   +7 more sources

Discovery of Novel Small-Molecule Inhibitors of PD-1/PD-L1 Interaction via Structural Simplification Strategy

open access: yesMolecules, 2021
Blockade of the programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction is currently the focus in the field of cancer immunotherapy, and so far, several monoclonal antibodies (mAbs) have achieved encouraging outcomes in cancer ...
Hongbo Zhang   +9 more
doaj   +1 more source

Optimization design in single wagon-wheel fuel grain of hybrid rocket motor

open access: yesFirePhysChem, 2021
The grain design of hybrid rocket motor is a design of proper fuel grain geometry and flow adjustment scheme based on the total impulse, thrust, chamber pressure, length and outer diameter of combustion chamber.
Wei Tianfang   +5 more
doaj   +1 more source

Forward or Backward: Lessons Learned from Small Molecule Drugs Approved by FDA from 2012 to 2022

open access: yesMolecules, 2023
At every juncture in history, the design and identification of new drugs pose significant challenges. To gain valuable insights for future drug development, we conducted a detailed analysis of New Molecular Entitiy (NME) approved by the Food and Drug ...
Mingxiao Gu   +3 more
doaj   +1 more source

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