Results 21 to 30 of about 2,311,595 (304)
Forward or Backward: Lessons Learned from Small Molecule Drugs Approved by FDA from 2012 to 2022
Molecules, 2023 At every juncture in history, the design and identification of new drugs pose significant challenges. To gain valuable insights for future drug development, we conducted a detailed analysis of New Molecular Entitiy (NME) approved by the Food and Drug ...
Mingxiao Gu +3 more
doaj +1 more source
Wiring optimization explanation in neuroscience: What is Special about it? [PDF]
, 2019 This paper examines the explanatory distinctness of wiring optimization models in neuroscience. Wiring optimization models aim to represent the organizational features of neural and brain systems as optimal (or near-optimal) solutions to wiring ...
Barberis, Sergio Daniel
core +6 more sources
Fast design optimization of UWB antenna with WLAN Band-Notch [PDF]
, 2015 In this paper, a methodology for rapid design optimization of an ultra-wideband ( UWB) monopole antenna with a lower WLAN band-notch is presented. The band-notch is realized using an open loop resonator implemented in the radiation patch of the antenna ...
Bekasiewicz, A +3 more
core +2 more sources
Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope
Acta Pharmaceutica Sinica B, 2022 The proteolysis targeting chimeras (PROTACs) technology has been rapidly developed since its birth in 2001, attracting rapidly growing attention of scientific institutes and pharmaceutical companies.
Sinan Ma +10 more
doaj +1 more source
An optimization method for nacelle design [PDF]
, 2017 A multi-objective optimiZation method is demonstrated using an evolutionary genetic algorithm. The applicability of this method to preliminary nacelle design is demonstrated by coupling it with a response surface model of a wide range of nacelle designs.
Heidebrecht, A. +2 more
core +1 more source
SSRN Electronic Journal, 2010 This paper introduces three methodological advances to study the optimal design of static and dynamic markets. First, we apply a mechanism design approach to characterize all incentive-compatible market equilibria. Second, we conduct a normative analysis, i.e. we evaluate alternative competition and innovation policies from a welfare perspective. Third,
Boone, Jan, Goeree, Jacob K
openaire +6 more sources
Optimal Monitoring Design [PDF]
Econometrica, 2020 This paper considers a Principal–Agent model with hidden action in which the Principal can monitor the Agent by acquiring independent signals conditional on effort at a constant marginal cost. The Principal aims to implement a target effort level at minimal cost. The main result of the paper is that the optimal information‐acquisition strategy is a two‐
Georgiadis, George, Szentes, Balazs
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Optimal experimental design for optimal process design: A trilevel optimization formulation
AIChE Journal, 2019 AbstractTypical optimal experimental design (OED) methods aim at minimizing the covariance matrix of the estimated parameters regardless of the intended application of the model that is being estimated. This can unnecessarily increase the experimental costs.
Walz, Olga +2 more
openaire +3 more sources
Advances in Aerodynamics, 2022 Modeling high-dimensional aerodynamic data presents a significant challenge in aero-loads prediction, aerodynamic shape optimization, flight control, and simulation.
Bo-Wen Zan +4 more
doaj +1 more source
Multi-objective topology design optimization combined with robust optimization
Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2023 Topology optimization (TO), which is a design optimization technique that does not require design parameters, has been attracting attention. TO has a high degree of freedom and can obtain a novel design shape suitable for desired purposes.
Akito MARUO +4 more
doaj +1 more source