Results 21 to 30 of about 598,406 (269)

Optimal experimental design for optimal process design: A trilevel optimization formulation

open access: yesAIChE Journal, 2019
AbstractTypical optimal experimental design (OED) methods aim at minimizing the covariance matrix of the estimated parameters regardless of the intended application of the model that is being estimated. This can unnecessarily increase the experimental costs.
Walz, Olga   +2 more
openaire   +3 more sources

A-optimal design matrices

open access: yesDiscrete Mathematics, 1984
The tools in search of A-optimal designs are listed and the authors derive A-optimal chemical balance weighing designs (that is, \(N\times n\) matrices with elements 1, -1 and 0) for \(N\geq 7\), \(n\leq 6\).
Chi Song Wong, Joseph C. Masaro
openaire   +1 more source

Multi-objective topology design optimization combined with robust optimization

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2023
Topology optimization (TO), which is a design optimization technique that does not require design parameters, has been attracting attention. TO has a high degree of freedom and can obtain a novel design shape suitable for desired purposes.
Akito MARUO   +4 more
doaj   +1 more source

High-dimensional aerodynamic data modeling using a machine learning method based on a convolutional neural network

open access: yesAdvances in Aerodynamics, 2022
Modeling high-dimensional aerodynamic data presents a significant challenge in aero-loads prediction, aerodynamic shape optimization, flight control, and simulation.
Bo-Wen Zan   +4 more
doaj   +1 more source

‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents

open access: yesMolecules, 2017
DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of the Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro, but poor efficacy in vivo due to its poor
Xiang Li   +4 more
doaj   +1 more source

Optimal Queue Design

open access: yesProceedings of the 22nd ACM Conference on Economics and Computation, 2020
We study the optimal method for rationing scarce resources through a queue system. The designer controls agents' entry into a queue and their exit, their service priority -- or queueing discipline -- as well as their information about queue priorities, while providing them with the incentive to join the queue and, importantly, to stay in the queue ...
Yeon-Koo Che, Olivier Tercieux
openaire   +2 more sources

Optimal Market Design [PDF]

open access: yesSSRN Electronic Journal, 2010
This paper introduces three methodological advances to study the optimal design of static and dynamic markets. First, we apply a mechanism design approach to characterize all incentive-compatible market equilibria. Second, we conduct a normative analysis, i.e. we evaluate alternative competition and innovation policies from a welfare perspective. Third,
Boone, Jan, Goeree, Jacob K
openaire   +6 more sources

A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications

open access: yesEuropean Journal of Medicinal Chemistry Reports, 2022
Cycloastragenol (CAG) is a sapogenin of Astragaloside IV (AG-IV), isolated from the dried roots of legumes Astragalus mongolica or Astragalus membranaceus.
Mengting He   +7 more
doaj   +1 more source

Optimal Experimental Designs

open access: yesThe Annals of Mathematical Statistics, 1966
Abstract : This paper presents a number of results concerning the theory of the optimal design of experiments initiated and principal developed by Elfving, Kiefer and Wolfowitz. The paper contains approximately half expository and half new material. The proofs are mostly new and presented in a unified manner.
Karlin, Samuel, Studden, William J.
openaire   +2 more sources

Are Fertility Preservation Procedures Before Gonadotoxic Therapy and Hematopoietic Stem Cell Transplantation Feasible and Safe in Very Young Children? A Retrospective Cohort Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Fertility preservation (FP) is increasingly integrated into the care of pediatric patients exposed to gonadotoxic therapy or conditioning for hematopoietic stem cell transplantation (HSCT), yet perioperative data in infants and toddlers remain scarce.
Kerstin Saalabian   +13 more
wiley   +1 more source

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