Results 21 to 30 of about 11,290,757 (236)

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope

Acta Pharmaceutica Sinica B, 2022
The proteolysis targeting chimeras (PROTACs) technology has been rapidly developed since its birth in 2001, attracting rapidly growing attention of scientific institutes and pharmaceutical companies.
Sinan Ma, Jianai Ji, Yuanyuan Tong, Yuxuan Zhu, Junwei Dou, Xian Zhang, Shicheng Xu, Tianbao Zhu, Xiaoli Xu, Qidong You, Zhengyu Jiang   +10 more
doaj   +1 more source

A Framework for Situated Design Optimization [PDF]

, 2006
This paper presents a framework for situated design optimization that expands the traditional view of design optimization. It is based on the notion of interaction providing the potential for modifications of various aspects of the optimization process ...
John S. Gero, U. Kannengiesser, Udo Kannengiesser, J.S. Gero   +3 more
core   +1 more source

Replication Data for: eSLP optimization algorithm

, 2023
m-files implementing the eSLP optimization algorithm for the three simulations (3.1. - 3.3.) described in the associated paper. File README.txt contains analytical directions regarding requirements, how to verify the results and videos generated by the ...
Optimization, eSLP
core   +1 more source

High-dimensional aerodynamic data modeling using a machine learning method based on a convolutional neural network

Advances in Aerodynamics, 2022
Modeling high-dimensional aerodynamic data presents a significant challenge in aero-loads prediction, aerodynamic shape optimization, flight control, and simulation.
Bo-Wen Zan, Zhong-Hua Han, Chen-Zhou Xu, Ming-Qi Liu, Wen-Zheng Wang   +4 more
doaj   +1 more source

Multi-objective topology design optimization combined with robust optimization

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2023
Topology optimization (TO), which is a design optimization technique that does not require design parameters, has been attracting attention. TO has a high degree of freedom and can obtain a novel design shape suitable for desired purposes.
Akito MARUO, Norihiko ITANI, Ayano HASOME, Takashi YAMAZAKI, Hajime IGARASHI   +4 more
doaj   +1 more source

‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents

Molecules, 2017
DDO-6101, a natural-product-like caged xanthone discovered previously in our laboratory based on the pharmacophoric scaffold of the Garcinia natural product gambogic acid (GA), shows potent cytotoxicity in vitro, but poor efficacy in vivo due to its poor
Xiang Li, Yue Wu, Yanyan Wang, Qidong You, Xiaojin Zhang   +4 more
doaj   +1 more source

Multidisciplinary design optimization framework for the pre design stage [PDF]

, 2010
Presented is a novel framework for performing flexible computational design studies at preliminary design stage. It incorporates a workflow management device (WMD) and a number of advanced numerical treatments, including multi-objective optimization ...
Balachandran, Libish Kalathil, Padulo, Mattia, Paolo Fantini, Nunez, Marco, Marin Guenov, Libish Balachandran, Guenov, Marin D., Maginot, Jeremy, Marco Nunez, Mattia Padulo, Jeremy Maginot, Fantini, Paolo   +11 more
core   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Rational design of carbazole-based STING inhibitors for treating cGAS-STING pathway-driven inflammatory disorders

Nature Communications
Stimulator of Interferon Genes (STING) is a pivotal adaptor protein in the innate immune pathway, and its aberrant activation is closely associated with the pathogenesis of autoimmune diseases.
Hui Li, Wei Zheng, Wenjing Bian, Mei Li, Zhidan Fan, Ziwen Feng, Xiaoyan Liu, Shiduo Zhang, Haohao Lu, Yinquan Huang, Jiaqing Jia, Yifan Zhang, Linlin Li, Chunchen Che, Haiguo Yu, Yibei Xiao, Qidong You, Xiaoli Xu   +17 more
doaj   +1 more source