Results 71 to 80 of about 903,165 (318)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Integrated qualitativeness in design by multi-objective optimization and interactive evolutionary computation. [PDF]

, 2005
- The concept of qualitativeness in design is an important one, and needs to be incorporated in the optimization process for a number of reasons outlined in this paper.
Ramsden, Jeremy, Tiwari, Ashutosh, Brintrup, Alexandra Melike, Ramsden, Jeremy J., Brintrup, Alexandra   +4 more
core  

A hybrid one-then-two stage algorithm for computationally expensive electromagnetic design optimization

, 2006
A novel kriging-assisted algorithm is proposed for computationally expensive single-objective optimization. The principle behind the algorithm is to use information about objective function space at the earliest possible opportunity. After constructing a
G. I. Hawe, Hawe, G. I., Jan Sykulski, Sykulski, J. K., Hawe, G., Sykulski, J.K., J. K. Sykulski, Glenn Hawe   +7 more
core   +1 more source

Development of Novel Nrf2/ARE Inducers Bearing Pyrazino[2,1-a]isoquinolin Scaffold with Potent In Vitro Efficacy and Enhanced Physicochemical Properties

Molecules, 2017
Pyrazino[2,1-a]isoquinolin analogues were reported as potent activators of Nrf2/ARE signaling both in vitro and in vivo by our group. In this study, we simplified the ring system to investigate the functions of various parts of the pyrazino[2,1-a ...
Hongbin Dai, Qiong Jiao, Tian Liu, Qidong You, Zhengyu Jiang   +4 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Flux Weakening Strategy Optimization for Five-Phase PM Machine with Concentrated Windings [PDF]

, 2012
The paper applies an Efficient Global Optimization method (EGO) to improve the efficiency, in flux weakening region, of a given 5-phase Permanent Magnet (PM) machine. An optimal control for the four independent currents is thus defined.
JILIN, Gong, ASLAN, Bassel, SEMAIL, Eric, GILLON, Frédéric   +3 more
core  

Identification of Inhibitors of the Anti-Infective Target DXS Using Dynamic Combinatorial Chemistry

Proceedings, 2019
Antibiotic resistance is one of the biggest threats to humankind [1,2]. [...]
Ravindra P. Jumde, Alaa Alhayek, Robin M. Gierse, Anna K. H. Hirsch   +3 more
doaj   +1 more source

Robustness of A-optimal designs

Linear Algebra and its Applications, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Masaro, Joe, Wong, Chi Song
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Parametric design and optimization of high speed train nose [PDF]

, 2016
Aiming at shortening the design period and improve the design efficiency of the nose shape of high speed trains, a parametric shape optimization method is developed for the design of the nose shape has been proposed in the present paper based on the VMF ...
孙振旭, 杨国伟, Sun, ZX (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Applicat Mech Engn Syst, Beijing 100190, Peoples R China., 姚拴宝, 郭迪龙, 陈大伟   +5 more
core   +1 more source