Results 111 to 120 of about 17,265,464 (329)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Metallic nanomedicine in cancer immunotherapy

Acta Pharmaceutica Sinica B
Immunotherapy has become a pivotal modality in clinical cancer treatment. However, its effectiveness is limited to a small subset of patients due to the low antigenicity, impaired innate response, and various adaptive immune resistance mechanisms of the ...
Shixuan Li, Xiaohu Wang, Huiyun Han, Shuting Xiang, Mingxi Li, Guangyu Long, Yanming Xia, Qiang Zhang, Suxin Li   +8 more
doaj   +1 more source

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

Frontiers in Microbiology, 2017
Pseudomonas aeruginosa is a Gram-negative bacterium, which causes opportunistic infections in immuno-compromised individuals. Due to its multiple resistances toward antibiotics, the development of new drugs is required.
Giuseppe Allegretta, Christine K. Maurer, Jens Eberhard, Damien Maura, Damien Maura, Damien Maura, Rolf W. Hartmann, Rolf W. Hartmann, Laurence Rahme, Laurence Rahme, Laurence Rahme, Martin Empting   +11 more
doaj   +1 more source

Inverse design of a binary waveguide crossing by the particle swarm optimization algorithm

, 2022
Kiyanoush Goudarzi, Moonjoo Lee
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Stability Analysis of Neural Networks-Based System Identification

Modelling and Simulation in Engineering, 2008
This paper treats some problems related to nonlinear systems identification. A stability analysis neural network model for identifying nonlinear dynamic systems is presented.
Talel Korkobi, Mohamed Djemel, Mohamed Chtourou   +2 more
doaj   +1 more source

Interaction Design With Multi-Objective Bayesian Optimization

, 2023
Yi-Chi Liao, John J. Dudley, George Mo, Chun-Lien Cheng, Liwei Chan, Antti Oulasvirta, Per Ola Kristensson   +6 more
openalex   +2 more sources

The Sizing and Optimization Language (SOL): A computer language to improve the user/optimizer interface [PDF]

The nonlinear mathematical programming method (formal optimization) has had many applications in engineering design. A figure illustrates the use of optimization techniques in the design process. The design process begins with the design problem, such as
Lucas, S. H., Scotti, S. J.
core   +1 more source

Computational Bounds For Photonic Design

, 2019
Physical design problems, such as photonic inverse design, are typically solved using local optimization methods. These methods often produce what appear to be good or very good designs when compared to classical design methods, but it is not known how ...
Angeris, Guillermo, Boyd, Stephen, Vuckovic, Jelena   +2 more
core   +2 more sources