Results 161 to 170 of about 903,165 (318)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Comparison between Gradient-free and Adjoint Based Aerodynamic Optimization of a Flying Wing Transport Aircraft in the Preliminary Design.

, 2007
This paper describes investigations of planform and shape optimizations for a flying wing transport aircraft with an Euler continuous adjoint method.
Arno, Ronzheimer, Martin, Hepperle, Widhalm, Markus   +2 more
core  

Electrosprayed PLGA Nanoparticles for Dual Drug Delivery: Design, Optimization and Applications. [PDF]

Polymers (Basel)
Azimi B, Ahmadpoor F, Tozzi A, Shahraki A, Maleki H, Ferrari PF, Danti S.   +6 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Ant colony optimization based simulation of 3d automatic hose/pipe routing

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis focuses on applying one of the rapidly growing non-deterministic optimization algorithms, the ant colony algorithm, for simulating automatic ...
Thantulage, Gishantha I F
core  

Design, optimization and characterization of mucoadhesive buccal film as a novel delivery system for doxazosin mesylate. [PDF]

Saudi Pharm J
Maraie NK, Wannas AN.
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

MULTI-OBJECTIVE OPTIMIZATION IN AXIAL COMPRESSOR DESIGN USING A LINKED CFD-SOLVER

, 2008
In combination with a multi-objective 3D optimization strategy, a linked CFD-solver is introduced in this paper, combining 3D-Reynolds-averaged-Navier-Stokes and an inviscid through-flow method.
Lawerenz, Martin, Becker, Kai, Voss, Christian   +2 more
core  

Stochastic Multilayer Optimization for an Acrylic Acid Reactor

ACS Omega, 2021
Andrés Duque, Silvia Ochoa, Darci Odloak   +2 more
doaj   +1 more source

A hybrid simulation-machine learning proxy model for waterflood design optimization in the Bahariya Formation. [PDF]

Sci Rep
Gad R, Salem AM, El Farouk OM, El-Hoshoudy AN.   +3 more
europepmc   +1 more source