Results 131 to 140 of about 4,809,223 (287)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
IEEE AccessMicroservices architecture offers theoretical benefits for software maintainability, yet empirical validation of design patterns’ effectiveness for enhancing modifiability remains limited, with practitioners lacking evidence-based guidance for ...
Gintoro +4 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
BuildingsAs China’s urbanization rate continues to rise, the scale of high-rise residences also grows, emerging as one of the main sources of building energy consumption and carbon emissions.
Teng Shao +4 more
doaj +1 more source
Empirical study of the relationship between design patterns and code smells. [PDF]
PLoS One, 2020 Alfadel M, Aljasser K, Alshayeb M.
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
A multiflare horn with 1-megawatt power handling capability [PDF]
The design and testing of the prototype horn for the proposed 1-megawatt radar are described. The unique features of this square horn include a multiflare design in which flare angle changes rather than corrugations are used to generate the required ...
Hoppe, D. J.
core +1 more source
Designing moiré patterns by strain
Physical Review ResearchExperiments conducted on two-dimensional twisted materials have revealed a plethora of moiré patterns with different forms and shapes. The formation of these patterns is usually attributed to the presence of small strains in the samples, which typically arise during their fabrication.
Federico Escudero +4 more
openaire +4 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source