Results 141 to 150 of about 13,502,506 (299)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Maintainable Control Software Design Using Design Patterns in IEC 61499
IEEE Open Journal of the Industrial Electronics SocietyControl software design in cyber-physical systems plays a vital role in ensuring maintainability and adaptability in response to evolving process requirements.
Shubham Sharma +3 more
doaj +1 more source
Hybrid modeling design patterns
Journal of Mathematics in IndustryAbstractDesign patterns provide a systematic way to convey solutions to recurring modeling challenges. This paper introduces design patterns for hybrid modeling, an approach that combines modeling based on first principles with data-driven modeling techniques.
Maja Rudolph +2 more
openaire +5 more sources
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Empirical study of the relationship between design patterns and code smells. [PDF]
PLoS One, 2020 Alfadel M, Aljasser K, Alshayeb M.
europepmc +1 more source
Applied SciencesThis paper presents Geo-Esthetics, an application-oriented workflow that uses remote sensing imagery as source morphology for generative design. The study addresses a design problem: how can large-scale terrestrial textures be extracted, abstracted, and ...
Jiawen Xu +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Temporal Design Patterns for Digital Phenotype Cohort Selection in Critical Care: Systematic Literature Assessment and Qualitative Synthesis. [PDF]
JMIR Med Inform, 2020 Capurro D +4 more
europepmc +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source