Results 101 to 110 of about 31,965,129 (228)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Performance Optimization of Triangular Cantilever Beam Piezoelectric Energy Harvesters: Synergistic Design Research on Mass Block Structure Optimization and Negative Poisson's Ratio Substrate. [PDF]

Micromachines (Basel)
Ren R, Li B, Liu J, Zhang Y, Xu G, Liu W.   +5 more
europepmc   +1 more source

Common Shortcomings in Study on Radiopharmaceutical Design Research: A Case Study of ^99mTc-Labelled Methotrexate. [PDF]

Molecules, 2021
Koźmiński P, Halik PK, Chesori R, Gniazdowska E.   +3 more
europepmc   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Action design research to develop an interactive dashboard to visualise and compare patient data from Irish general practice (CARA). [PDF]

BMJ Open
Vornhagen H, Garzón-Orjuela N, Stasiewicz K, Garcia Pereira A, Parveen S, Porwol L, Collins C, Blake C, Vellinga A.   +8 more
europepmc   +1 more source

Educational design research: Portraying, conducting, and enhancing productive scholarship. [PDF]

Med Educ, 2021
McKenney S, Reeves TC.
europepmc   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Molecular biology and design research : A new paradigm and transdisciplinary approach to communicating science. [PDF]

EMBO Rep
Molins-Pitarch C, Krebs J, Brena D.
europepmc   +1 more source

Developing a dementia inclusive hospital environment using an Integrated Care Pathway design: research protocol. [PDF]

PeerJ, 2021
Riquelme-Galindo J, Lillo-Crespo M.
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source