Results 121 to 130 of about 14,419,973 (304)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Are we there yet? Insights to support the use of reflective practice methods for explorative practice-led doctoral research into real-world design problems [PDF]

open access: yes, 2009
This paper concerns the use of design thinking in practice-led doctoral design research. It examines methodological appropriateness for research through design.
Spencer, Nick, Young, Robert
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A degree of employability: a research agenda towards curricula design [PDF]

open access: yes, 2014
The challenge of providing commercial science and technology skills in an academic environment stimulates considerable debate, with industry suggesting it cannot be done. In investigating enhancing employability skills of STEM graduates many institutions
Morrell, Carole, Morrell, Mandy
core  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

In Another Life Another Being: On Design and the Wages of Decoloniality

open access: yesDiseña
Despite the struggles for design disciplines to confront their colonial legacies and practices, the question remains: who can truly afford a decolonizing practice worthy of the name?
Jomy Joseph
doaj   +1 more source

Unified control/structure design and modeling research [PDF]

open access: yes
To demonstrate the applicability of the control theory for distributed systems to large flexible space structures, research was focused on a model of a space antenna which consists of a rigid hub, flexible ribs, and a mesh reflecting surface.
Adamian, A.   +3 more
core   +1 more source

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