Results 201 to 210 of about 7,571,405 (316)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Developing a dementia inclusive hospital environment using an Integrated Care Pathway design: research protocol. [PDF]

PeerJ, 2021
Riquelme-Galindo J, Lillo-Crespo M.
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Design research on a smart infusion device to reduce medical workload and enhance patient safety. [PDF]

Sci Rep
Mu B, Wang Y, Liu X, Bebit MP, Chen M, Wu H, Zhang W, Wang L, Fang Y, Dong K.   +9 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Bibliometrics Analysis and Knowledge Mapping of Fragment-Based Drug Design Research: Trends from 2015 to 2024. [PDF]

Drug Des Devel Ther
He C, Zhang J, Zhang R, Liu L, Luo J, Zhang W, Fang B.   +6 more
europepmc   +1 more source

Rectus Femoris Mimicking Ultrasound Phantom for Muscle Mass Assessment: Design, Research, and Training Application. [PDF]

J Clin Med, 2021
Nakanishi N, Inoue S, Tsutsumi R, Akimoto Y, Ono Y, Kotani J, Sakaue H, Oto J.   +7 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Implementing IPE in a Workplace Setting: Educational Design Research Promotes Transformative Participation. [PDF]

Perspect Med Educ
Versluis MAC, Zöllner LS, Papadopoulou S, van der Stouwe R, de Haan-Gremme MC, Tsiamparlis-Wildeboer AHC, Helmholt H, de Carvalho-Filho MA.   +7 more
europepmc   +1 more source