Results 181 to 190 of about 7,571,405 (316)

The Need for a Paradigm Shift in Approaching Ageing-Related Design Research and Practice. [PDF]

Front Psychol, 2021
Comincioli E, Chirico A, Gaggioli A, Masoodian M.   +3 more
europepmc   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Establishing One Health Surveillance Platform for Electronic Integrated Disease Surveillance and Response in Malawi: Action Design Research Study. [PDF]

JMIR Public Health Surveill
Wu TJ, Mvula MV, Chado EKK, Kamanga BN, Mapemba DD, Billy RE, Nyirongo L, Mwale AC, Banda EC, Kagoli M, Manda TD, Bjune GA, Kaasbøll JJ.   +12 more
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Design Rationale and Preliminary Evaluation of a Prototype Designed by People With Lived Experience of Psychosis and Professionals: Design Research Study. [PDF]

J Particip Med
Veldmeijer L, Terlouw G, Van 't Veer J, Van Os J, Boonstra N.   +4 more
europepmc   +1 more source

Virtual Deliberate Practice Module for Tracheostomy Change Training: An Application of Educational Design Research. [PDF]

ATS Sch, 2022
Benjamin JC, Flores S, Jain P, Kumar S, Thammasitboon S.   +4 more
europepmc   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A Collaborative Communities-of-Practice Methodology for Environmental Design Research: A Case Study Application in Palliative Care. [PDF]

HERD
Jonescu EE, Farrell B, Ramanayaka CE, Delaney L, Litton E, Uylaki TJ, Watts G, Brigham B, Bellemore F, Seah D.   +9 more
europepmc   +1 more source

The Smart Nervous System for Cracked Concrete Structures: Theory, Design, Research, and Field Proof of Monolithic DFOS-Based Sensors. [PDF]

Sensors (Basel), 2022
Bednarski Ł, Sieńko R, Howiacki T, Zuziak K.   +3 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source