Results 161 to 170 of about 14,419,973 (304)

Dimensions of design space: a decision-theoretic approach to optimal research design [PDF]

Bayesian decision theory can be used not only to establish the optimal sample size and its allocation in a single clinical study, but also to identify an optimal portfolio of research combining different types of study design.
Karl Claxton, Stefano Conti
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Involving family caregivers in co-design research: a systematic review protocol for developing evidence-based engagement strategies. [PDF]

BMJ Open
Alfaro-Diaz C, Rothausen CS, Bonde Hansen EV, Samuelsson M.   +3 more
europepmc   +1 more source

Design Research to Embed mHealth into a Community-Led Blood Pressure Management System in Uganda: Protocol for a Mixed Methods Study.

JMIR Res Protoc, 2023
Schwab J, Wachinger J, Munana R, Nabiryo M, Sekitoleko I, Cazier J, Ingenhoff R, Favaretti C, Subramonia Pillai V, Weswa I, Wafula J, Emmrich JV, Bärnighausen T, Knauf F, Knauss S, Nalwadda CK, Sudharsanan N, Kalyesubula R, McMahon SA.   +18 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Beyond a buzzword: the need for shared language, education, and enhanced reporting of disability inclusive co-design research. [PDF]

Res Involv Engagem
Chapman K, Yi J, Norwood M, Clanchy K, Carlini J, Shirota C, Mann M, Mitchell J, Kendall E.   +8 more
europepmc   +1 more source

Virtual Deliberate Practice Module for Tracheostomy Change Training: An Application of Educational Design Research. [PDF]

ATS Sch, 2022
Benjamin JC, Flores S, Jain P, Kumar S, Thammasitboon S.   +4 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishing One Health Surveillance Platform for Electronic Integrated Disease Surveillance and Response in Malawi: Action Design Research Study. [PDF]

JMIR Public Health Surveill
Wu TJ, Mvula MV, Chado EKK, Kamanga BN, Mapemba DD, Billy RE, Nyirongo L, Mwale AC, Banda EC, Kagoli M, Manda TD, Bjune GA, Kaasbøll JJ.   +12 more
europepmc   +1 more source

DeResA: a DEsign RESearch Approach [PDF]

, 2006
Slettenhaar, H.K., Vries, S.A. de
core   +1 more source