Results 171 to 180 of about 14,419,973 (304)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Design Rationale and Preliminary Evaluation of a Prototype Designed by People With Lived Experience of Psychosis and Professionals: Design Research Study. [PDF]

J Particip Med
Veldmeijer L, Terlouw G, Van 't Veer J, Van Os J, Boonstra N.   +4 more
europepmc   +1 more source

The Smart Nervous System for Cracked Concrete Structures: Theory, Design, Research, and Field Proof of Monolithic DFOS-Based Sensors. [PDF]

Sensors (Basel), 2022
Bednarski Ł, Sieńko R, Howiacki T, Zuziak K.   +3 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

A Collaborative Communities-of-Practice Methodology for Environmental Design Research: A Case Study Application in Palliative Care. [PDF]

HERD
Jonescu EE, Farrell B, Ramanayaka CE, Delaney L, Litton E, Uylaki TJ, Watts G, Brigham B, Bellemore F, Seah D.   +9 more
europepmc   +1 more source

Ageing well with diabetes: A workshop to co-design research recommendations for improving the diabetes care of older people. [PDF]

Diabet Med, 2022
Wylie TAF, Morris A, Robertson E, Middleton A, Newbert C, Andersen B, Maltese G, Stocker R, Weightman A, Sinclair A, Bain SC.   +10 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Performance Optimization of Triangular Cantilever Beam Piezoelectric Energy Harvesters: Synergistic Design Research on Mass Block Structure Optimization and Negative Poisson's Ratio Substrate. [PDF]

Micromachines (Basel)
Ren R, Li B, Liu J, Zhang Y, Xu G, Liu W.   +5 more
europepmc   +1 more source

Common Shortcomings in Study on Radiopharmaceutical Design Research: A Case Study of ^99mTc-Labelled Methotrexate. [PDF]

Molecules, 2021
Koźmiński P, Halik PK, Chesori R, Gniazdowska E.   +3 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source