Results 171 to 180 of about 61,817,433 (314)

Promote collaborations in online problem-based learning in a user experience design course: Educational design research. [PDF]

Educ Inf Technol (Dordr), 2023
Zhu M, Zhang K.
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

How to Explain Design Research To Your Friends

Drawing inspiration from Paulo Freire's liberation pedagogy, this paper proposes a shift from the traditional ‘banking’ model to a 'problem-posing' approach in design research.
Stephens, Noelyn, Xiao, Yiqi, Thomas, Nekita, Pridemore, Joshua, Strickland, Holly, Benson, Eric   +5 more
core   +1 more source

Engaging students in an AI-driven RNA drug design research project through a crowd science-infused learning approach. [PDF]

J Microbiol Biol Educ
Bhattacharjee K, Idres YM, Deb S, Gao W, Idris A.   +4 more
europepmc   +1 more source

User Experience of the Co-design Research Approach in eHealth: Activity Analysis With the Course-of-Action Framework. [PDF]

JMIR Hum Factors, 2022
Tremblay M, Hamel C, Viau-Guay A, Giroux D.   +3 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Metallurgical Thermodynamic Design Research on the In Situ Synthesis of Ti-Al-Nb Alloys Using Thermit Self-Propagating Reduction. [PDF]

Materials (Basel)
Jiang H, Zhang T, Dou Z.
europepmc   +1 more source

A pedagogical model to enhance nurses' ability to support patient learning: an educational design research study. [PDF]

Int J Med Educ, 2022
Engqvist Boman L, Sundberg K, Petersson LM, Backman M, Silén C.   +4 more
europepmc   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Involving family caregivers in co-design research: a systematic review protocol for developing evidence-based engagement strategies. [PDF]

BMJ Open
Alfaro-Diaz C, Rothausen CS, Bonde Hansen EV, Samuelsson M.   +3 more
europepmc   +1 more source