Results 91 to 100 of about 5,060,080 (299)

Space Station Engineering Design Issues [PDF]

Space Station Freedom topics addressed include: general design issues; issues related to utilization and operations; issues related to systems requirements and design; and management issues relevant to ...
Boehm, Barry W., Debra, Daniel B., Green, C. Cordell, Henry, Richard C., Maycock, Paul D., Mcelroy, John H., Mcruer, Duane T., Pierce, Chester M., Stafford, Thomas P., Young, Laurence R.   +9 more
core   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Computer-Aided Design of Digital Compensators for DC/DC Power Converters

Energies, 2018
Digital control of high-frequency power converters has been used extensively in recent years, providing flexibility, enhancing integration, and allowing for smart control strategies. The core of standard digital control is the discrete linear compensator,
Pablo Zumel, Cristina Fernández, Marlon A. Granda, Antonio Lázaro, Andrés Barrado   +4 more
doaj   +1 more source

Open Space Design

Open space design: managing urban complexity is the result of an interdisciplinary research experience conducted by the authors in the fields of technological-environmental design and multi-scalar parametric modeling. The thematic chapters develop topics from the suggestions provided by the discussion with DREISEITLconsulting regarding the strategic ...
Rossella Franchino, Caterina Frettoloso, Nicola Pisacane   +2 more
openaire   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Parameter Optimization Considering the Variations Both from Materials and Process: A Case Study of Scutellaria baicalensis Extract

Separations
The Quality by Design (QbD) concept has been widely applied to the optimization of traditional Chinese medicine production processes recently. This work focused on optimizing the critical purification process of Scutellaria baicalensis extract used in ...
Xuecan Zhang, Zhilong Tang, Bo Chen, Xingchu Gong   +3 more
doaj   +1 more source

Space Math: Solar Storms and You! Exploring Satellite Design [PDF]

, 2000
This educator’s guide includes activities in space science.
Sten Odenwald
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Design considerations for a space database [PDF]

Part of the information used in a real-time simulator is stored in the visual database. This information is processed by an image generator and displayed as a real-time visual image.
Moss, Lance M.
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source