Results 181 to 190 of about 5,060,080 (299)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Determination and validation of design space for mesenchymal stem cell cultivation processes using prediction intervals. [PDF]

Commun Biol
Hirono K, Hayashi Y, A Udugama I, Gaddem MR, Tanaka K, Takemoto Y, Kato R, Kino-Oka M, Sugiyama H.   +8 more
europepmc   +1 more source

Expanding Biomaterial Surface Topographical Design Space through Natural Surface Reproduction. [PDF]

Adv Mater, 2021
Vermeulen S, Honig F, Vasilevich A, Roumans N, Romero M, Dede Eren A, Tuvshindorj U, Alexander M, Carlier A, Williams P, Uquillas J, de Boer J.   +11 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A Mathematical Model for Determining Probabilistic Design Space in Mesenchymal Stem Cell Passage Culture. [PDF]

Biotechnol Bioeng
Hirono K, Hayashi Y, Ogawa Y, Kino-Oka M, Sugiyama H.   +4 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

The design space of E(3)-equivariant atom-centred interatomic potentials. [PDF]

Nat Mach Intell
Batatia I, Batzner S, Kovács DP, Musaelian A, Simm GNC, Drautz R, Ortner C, Kozinsky B, Csányi G.   +8 more
europepmc   +1 more source

Controlled Polymerization of Norbornene Cycloparaphenylenes Expands Carbon Nanomaterials Design Space. [PDF]

ACS Cent Sci, 2021
Maust RL, Li P, Shao B, Zeitler SM, Sun PB, Reid HW, Zakharov LN, Golder MR, Jasti R.   +8 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Assessing Design Space for the Device-Circuit Codesign of Nonvolatile Memory-Based Compute-in-Memory Accelerators. [PDF]

Nano Lett
Lele AS, Zhang B, Khwa WS, Chang MF.
europepmc   +1 more source