Results 101 to 110 of about 4,669,215 (266)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Study designs

open access: yesInternational Journal of Ayurveda Research, 2010
Parab, Shraddha, Bhalerao, Supriya
openaire   +3 more sources

Study Designs in Medicine

open access: yesBalkan Medical Journal, 2015
Scientific studies can be described as “a planned and systematic effort based on evidence for the solution of any health problems using data with high degree of accuracy” (1). The main aims are to quantify disease prevalence, and compare interventions, predictions, association assessments or etiology assessments (2).
openaire   +4 more sources

Effects of 3D-printed concrete permanent formwork on the flexural behavior of reinforced concrete beams: Experimental and analytical investigations

open access: yesCase Studies in Construction Materials
In response to challenges such as skilled labor shortages, reduced productivity, and the slow pace of digital transformation, 3D concrete printing (3DCP) offers a promising solution.
Tae-Kyung Kim   +6 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Wearable Electronic Textile Systems for Health Monitoring: A Review of Advances and Adoption Challenges

open access: yesNano Select
Wearable electronic textiles have played a significant role in healthcare delivery over the past few years. The desired characteristics of textiles, such as softness, flexibility, air permeability, and lightweight, coupled with their ability to withstand
George Kwame Fobiri   +9 more
doaj   +1 more source

Discovery of Octahydroisoindolone as a Scaffold for the Selective Inhibition of Chitinase B1 from Aspergillus fumigatus: In Silico Drug Design Studies. [PDF]

open access: yesMolecules, 2021
Marbán-González A   +4 more
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

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