Results 121 to 130 of about 10,358,166 (300)
Systems thinking in design education - the case study of mobility as a service [PDF]
Designers are faced with more complex, environmental and societal challenges than ever before. Those challenges require the ability to see how things are interrelated in the bigger picture and to analyse multiple causes and effects, rather than working ...
Preston, John +4 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Designing a Design Thinking Approach to HRD [PDF]
, 2019 This article considers the value of design thinking as applied to a HRD context, Specifically, it demonstrates how design thinking can be employed through a case study drawn from the GETM3 programme. It reports on the design, development, and delivery of a design thinking workshop which was created to draw out and develop ideas from students and recent
Bailey, Mark +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Design Thinking Applied: The Process of Creating a Technology-Mediated Debriefing Module [PDF]
, 2018 This qualitative case study explored the effectiveness of using design thinking to create a technology-mediated debriefing module (mock up/story board) for practical nursing students.
Taberner, Christy
core
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Applying Design Thinking Elsewhere: Organizational context matters [PDF]
, 2014 In this contribution design thinking is taken as a transfer of design methods from product development to other domains. It is argued that the success of this transfer depends on the organisational context offered to design thinking in these other ...
Smulders, F.E.H.M. +5 more
core +1 more source
, 2022 LAUREA MAGISTRALEIl design thinking ha dimostrato più volte la sua efficacia in tutti i settori. Ha permesso di innovare prodotti, servizi e sistemi. Tuttavia, i designer sono spesso messi in difficoltà da controparti non designer quando implementano ...
Dubus, Elisabeth
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source