Results 101 to 110 of about 359,417 (313)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Measuring the effectiveness of programmed instructions (PI) to learn design thinking concepts for secondary school students

Design Science
Self-instructional media in education has the potential to address educational challenges such as accessibility, flexible and personalised learning, real-time assessment and resource efficiency.
Apoorv Naresh Bhatt, Amaresh Chakrabarti
doaj   +1 more source

Fostering design culture through cultivating the user-designers’ design thinking and systems thinking

, 2014
[[abstract]]In this paper, the essence of design thinking and systems thinking is reviewed, analyzed, and synthesized. Although there are many valuable schools of systems thinking, I focus on both Banathy's and Senge's since there are design spirit ...
Li, M. F.
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CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Framework for Design Thinking Outside the Design Profession: An Analysis of Design Thinking Implementations

Journal of Architectural/Planning Research and Studies (JARS), 2019
Over the past decade, the term “design thinking” has received increasing attention in a wide range of contexts and has become increasingly familiar beyond the professional design arena. Exploration of potential cross-boundary engagements and the role of design as an agent of change for both innovation and social transformation are two main mechanisms ...
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Components of Design Thinking in Spatial Design Education and a Model Proposal

Iconarp International Journal of Architecture and Planning
Design thinking, defined in its simplest form as a creative problem-solving process, is interpreted in various ways in the literature, with differing models and components.
ipek yıldırım coruk
doaj   +1 more source

Application of the design strategy that is supported by lateral thinking techniques in product design [PDF]

Journal of Architecture, Art & Humanistic Science
Lateral thinking methods have a key role in developing the designer's ability to deal with challenges and life situations in a more creative way. It gives him the power to produce original and unique ideas.
Ahmed Kassab, Sayed Abdou Ahmed Abdou
doaj   +1 more source

Applying Design Thinking Elsewhere: Organizational context matters [PDF]

, 2014
In this contribution design thinking is taken as a transfer of design methods from product development to other domains. It is argued that the success of this transfer depends on the organisational context offered to design thinking in these other ...
Smulders, F.E.H.M., Dorst, K., Vermaas, P.E., Dorst, K, vermaas, P, Smulders, F   +5 more
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