Results 91 to 100 of about 359,417 (313)
Getting to grips with design thinking in interaction design : lessons from architectural practice
, 2012 In recent years, the concept of design thinking has received significant attention within the research literature originating from several design as well as management fields [1, 5]. However, there does not seem to be any agreement on what exactly design
Deshpande, Parag,
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Narrative in design development [PDF]
, 2013 19.12.13 KB. Ok to add the accepted version to sprial, publisher has given permissionThis paper describes the value of narrative used with ideation tools in aiding the rapid production of product concepts and designs for masters students of graphics ...
Childs, P, Grigg, J, ZHAO, Y
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2011 Design Things offers an innovative view of design thinking and design practice, envisioning ways to combine creative design with a participatory approach encompassing aesthetic and democratic practices and values.
De Michelis, Giorgio +5 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Proceedings of Relating Systems Thinking and Design (RSD5) 2016 Symposium
, 2016 All the proceedings of the Relating Systems Thinking and Design (RSD5) 2016 Symposium, held in Toronto, are published and available online as open access ...
Sevaldson, Birger +5 more
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Systems thinking in design education - the case study of mobility as a service [PDF]
Designers are faced with more complex, environmental and societal challenges than ever before. Those challenges require the ability to see how things are interrelated in the bigger picture and to analyse multiple causes and effects, rather than working ...
Preston, John +4 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Journal of Industrial Design and Engineering Graphics, 2015 Empathic design is often described as a creative process that translates observations - typically of people and their behaviours into design ideas.
FRAQUELLI Roberto
doaj
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source