Results 91 to 100 of about 2,162,136 (285)
Justifying the design and selection of literacy and thinking tools [PDF]
, 2008 Criteria for the design and selection of literacy and thinking tools that allow educators to justify what they do are described within a wider framework of learning theory and research into best practice.
Whitehead, David
core +2 more sources
Information system support in construction industry with semantic web technologies and/or autonomous reasoning agents [PDF]
, 2012 Information technology support is hard to find for the early design phases of the architectural design process. Many of the existing issues in such design decision support tools appear to be caused by a mismatch between the ways in which designers think ...
From +7 more
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Journal of Industrial Design and Engineering Graphics, 2015 Empathic design is often described as a creative process that translates observations - typically of people and their behaviours into design ideas.
FRAQUELLI Roberto
doaj
Uncertainty, learning design, and interdisciplinarity: systems and design thinking in the school classroom [PDF]
, 2014 This paper explores aspects of learning design for design thinking within a small (circa 100) remote rural secondary (12-18 year old) school in the Highlands of Scotland.
Macintyre, Ronald
core
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Design ScienceSelf-instructional media in education has the potential to address educational challenges such as accessibility, flexible and personalised learning, real-time assessment and resource efficiency.
Apoorv Naresh Bhatt, Amaresh Chakrabarti
doaj +1 more source
Design-Led Thinking for Improving Public Policy Performance [PDF]
, 2016 Introduction “Design is a funny word. Some people think design means how it looks. But of course, if you dig deeper, it\u27s really how it works,” said Steve Jobs in 1996.1 Design is an essential element of all public services.
Bholey, M. (Mihir)
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source