Results 81 to 90 of about 10,358,166 (300)

Design Thinking: Practice and Applications

, 2022
This chapter aims to address one common perception of design thinking—its ambiguous nature and transferability from theory to practice. Here, it features three contextually rich case studies provided by leading academics in the field of design and ...
Newton, Radka, Newton, Radka,, Baha, Ehsan, Aryana, Bijan,, Aryana, Bijan, Baha, Ehsan,   +5 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Sustainable Silica‐Carbon Nanofiber Hybrid Composite Anodes for Lithium‐Ion Batteries

Macromolecular Materials and Engineering
Alternative anode materials with increased theoretical specific capacities are under scrutinity as a replacement to graphite in lithium‐ion batteries (LiBs).
Anne Beaucamp, Amaia Moreno Calvo, Deaglán Bowman, Clotilde Techouyeres, David Mc Nulty, Erlantz Lizundia, Maurice N. Collins   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Getting to grips with design thinking in interaction design : lessons from architectural practice

, 2012
In recent years, the concept of design thinking has received significant attention within the research literature originating from several design as well as management fields [1, 5]. However, there does not seem to be any agreement on what exactly design
Deshpande, Parag,
core  

Referenciais teóricos e metodológicos para a prática do design thinking na educação básica [PDF]

, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia e Gestão do Conhecimento, Florianópolis, 2015.O design thinking tem sido aplicado na educação básica em diversos países do mundo,
Reginaldo, Thiago
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Geometric Thinking in Parametric Design Creativity: A Theory-Building Literature Analysis [PDF]

Journal of Design Thinking
This study develops a conceptual framework that elucidates the role of geometric thinking in fostering creativity within parametric design processes. While geometric thinking has long been recognized as central to spatial cognition in architecture and ...
Hosein Naseri, Mehdi Mahmoudi Kamelabad, Enrico De Angelis   +2 more
doaj   +1 more source

Design Things

, 2011
Design Things offers an innovative view of design thinking and design practice, envisioning ways to combine creative design with a participatory approach encompassing aesthetic and democratic practices and values.
De Michelis, Giorgio, Linde, Per, Wagner, Ina, Binder, Thomas, Jacucci, Giulio, Ehn, Pelle   +5 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source