Results 71 to 80 of about 2,162,136 (285)

Styling the Future. A philosophical account of scenarios & design [PDF]

, 2015
Since the end of the 1980s – the Decade of Style (Mort, 1996) – the value of style in design has fallen. Recent times (Whicher et al., 2015) see a focus on style as a sign of design’s immaturity, while a more mature design should be attending to process,
Brassett, Jamie, O'Reilly, John
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

O uso do design thinking como ferramenta no processo de inovação em bibliotecas

Encontros Bibli, 2017
http://dx.doi.org/10.5007/1518-2924.2017v22n49p59 Este artigo tem como finalidade apresentar estudos de casos de sucesso do uso da abordagem do Design Thinking (DT) em bibliotecas e teve como objetivo estudar o Design Thinking através da história, as ...
Diana Marcela Bernal Ramírez, Thais Batista Zaninelli   +1 more
doaj   +1 more source

The Design Postgraduate Journeyman: Mapping the relationship between design thinking and doing with skills acquisition for skilful practice [PDF]

, 2009
The relationship between knowing, doing and skillful practice resonate in industry and design education. The connection between creativity, design and successful innovation practices in industry has been debated much recently, heightened by realization ...
MacLarty, Liz, McKelvey, Kathryn, Young, Robert   +2 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Politics Design: A Solution-Oriented Approach to Political Science

Politicon
Post-behavioralist critiques are a crucial foundation for changes in previous apolitical political research. Politics should be an academic instrument and a response to humanity’s challenges. Political design seeks to criticize the dominance of the logic
Wawan Sobari
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Implementasi Design Thinking dalam Membangun Inovasi Model Bisnis Perusahaan Percetakan [PDF]

, 2016
Penelitian ini bertujuan untuk membagun Inovasi Model Bisnis berbasis Kanvas Model Bisnis dengan implementasi Design Thinking pada Perusahaan percetakan di Surabaya.
Saputra, T. A. (Tommy)
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source