Results 161 to 170 of about 2,154,958 (312)

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Du design thinking au design fiction

Technologie et Innovation
Thomas Michaud
doaj   +1 more source

Design Thinking Methodology as a Tool for the Formation of Innovative Solutions

, 2020
N. V. Vysotskaya, T. B. Kyrbatskaya
openalex   +1 more source

Teaching critical thinking about health information and choices in secondary schools: human-centred design of digital resources [PDF]

Sarah Rosenbaum, Jenny Moberg, Faith Chesire, Michael Mugisha, Ronald Ssenyonga, Marlyn Ochieng, Clarisse Marie Claudine Simbi, Esther Nakyejwe, Benson Ngatia, Gabriel Rada, Juan Vásquez-Laval, José Damián Garrido, Grace Baguma, Sam Kuloba, Edward Sebukyu, Richard Kabanda, Irene Mwenyango, Tonny Muzaale, Pamela Nandi, Jane Njue, Cyril Oyuga, Florian Rutiyomba, Felecien Rugengamanzi, Joan Murungi, Allen Nsangi, Daniel Semakula, Margaret Kaseje, Nelson K. Sewankambo, Laetitia Nyirazinyoye, Simon Lewin, Andrew D Oxman, Matt Oxman   +31 more
openalex   +1 more source

The Abduction of the Future Between inventive thinking and speculative design [PDF]

, 2022
Salvatore Zingale
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Integrating design thinking and agile approaches in analytics development: The case of Aginic [PDF]

, 2023
Edgar Brea, Ida Someh, Emma Freya, Brett Thebault, Shazia Sadiq   +4 more
openalex   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Reimagining Nursing Through Innovation and Design Thinking. [PDF]

Dela J Public Health
Rackie H, Pawlow PC.
europepmc   +1 more source

The Theoretical Background of Design Thinking for Public Sector Innovation [PDF]

Ilaria Mariani, Marzia Mortati, F. Rizzo, Alessandro Deserti   +3 more
openalex   +1 more source