Results 101 to 110 of about 4,227,388 (391)
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
„Dopalacze” – nieprzewidywalne narkotyki. Problem społeczno-prawny
Filozofia Publiczna i Edukacja Demokratyczna, 2019 The aim of this article is to present the problem of new psychoactive substances – designer drugs. New drugs are undoubtedly a social and legal problem.
Sebastian Matyjek
doaj +1 more source
The effect of 12 weeks Anethum graveolens (dill) on metabolic markers in patients with metabolic syndrome; A randomized double blind controlled trial [PDF]
, 2012 Background: The clustering of metabolic abnormalities defined as metabolic syndrome is now both a public health and a clinical problem .While interest in herbal medicine has greatly increased, lack of human evidence to support efficacies shown in animals
Hasani-Ranjbar, S. +5 more
core +3 more sources
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Ethics – research, engineering, design… they’re all the same aren’t they? [PDF]
, 2014 This paper considers how and to what extent product design ethics is understood by professionals in design practice and undergraduate students of product and engineering design and how, if at all, design ethics differ from engineering and/or research ...
Blount, G. +2 more
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Recent changes in drug abuse scenarios : The new/novel psychoactive substances (NPS) phenomenon [PDF]
, 2018 © 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Peer ...
Schifano, Fabrizio
core +2 more sources
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
The Crimes of Fashion: The Effects of Trademark and Copyright Infringement in the Fashion Industry [PDF]
, 2011 Counterfeits of designer merchandise continue to be made and sold throughout the world causing drastic social and economic outcomes everywhere. Despite the illegality of manufacturing and distributing counterfeit goods, this business has far-reaching ...
Marcelo, Carolyn
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