Results 141 to 150 of about 4,227,388 (391)
Development and Validation of a GC-MS Method for the Simultaneous Quantification of Two Piperazine Designer Drugs Sold in Combination as 'Legal X' [PDF]
, 2020 Patrícia Moreira +4 more
openalex +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
PharmacyIntroduction: The designer benzodiazepine (DBZD) market continues to expand whilst evading regulatory controls. The widespread adoption of social media by pro-drug use communities encourages positive discussions around DBZD use/misuse, driving demand ...
Anthony Mullin +9 more
doaj +1 more source
The curse of Frankenstein: visions of technology and society in the debate over new reproductive technologies [PDF]
, 2003 At each successive moment in their development new reproductive technologies have provided the occasion for virulent argument about the role of technology in human affairs. And more generally, technoscientific knowledge has long been held both in awe and
Bloomfield, B P, Vurdubakis, T
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
An Approach for Supporting Ad-hoc Modifications in Distributed Workflow Management Systems [PDF]
, 2007 Supporting enterprise-wide or even cross-organizational business processes is a characteristic challenge for any workflow management system (WfMS). Scalability at the presence of high loads as well as the capability to dynamically modify running workflow
Bauer, T., Reichert, M.U.
core +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Non‐Debye frustrated hydration steers biomolecular association: interfacial tension for the drug designer [PDF]
, 2016 Ariel Fernández
openalex +1 more source
An experience of modularity through design [PDF]
, 2001 We aim to utilise the experiences of a marine industry-based design team to determine the need for research into a modular design methodology in an industrial environment.
Duffy, Alex H.B. +4 more
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