Results 161 to 170 of about 4,227,388 (391)
Analysis of neuronal activity impairment in iPSC-derived neurons from idiopathic autism patients
iScienceSummary: Understanding the molecular mechanisms underlying autism spectrum disorder (ASD) is crucial to develop effective interventions. Here, we utilized induced pluripotent stem cells differentiated into neurons (iPSC-Ns) from idiopathic ASD and ...
Andras Kern +7 more
doaj +1 more source
Structural characterization of cathinone-type designer drugs by EI mass spectrometry
, 2014 Shuntaro Matsuta +12 more
openalex +2 more sources
PRODUCING OR MARKETING THE DESIGNER DRUGS AS AN OFFENCE FRoM ARTICLE 165 § 1 POINT 2 CC [PDF]
, 2018 Magdalena Kowalewska-Łukuć
openalex +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
, 2010 This exhibition was conceived by Dunne (PI) and comprised 16 mixed-media speculative design research projects. It marked the culmination of an EPSRC-funded initiative also partly supported by NESTA. Dunne supervised and then curated the projects by staff,
Dunne, Anthony, Raby, Fiona
core
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Educated Guesses and Other Ways to Address the Pharmacological Uncertainty of Designer Drugs [PDF]
, 2016 Moritz Berning, Anita Hardon
openalex +1 more source
The mathematical components of engineering expertise: the relationship between doing and understanding mathematics [PDF]
, 2002 this paper are extracts from our interviews with engineers.) Where, then, is the complex mathematics that certainly exists in modern engineering? Throughout all aspects of engineering design, computer software has an overwhelming presence.
Kent, Phillip, Noss, Richard
core +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source