Results 191 to 200 of about 4,227,388 (391)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Lyme disease: the promise of Big Data, companion diagnostics and precision medicine
Infection and Drug Resistance, 2016 Raphael B Stricker,1 Lorraine Johnson2 1International Lyme and Associated Diseases Society, Bethesda, MD, 2LymeDisease.org, Chico, CA, USA Abstract: Lyme disease caused by the spirochete Borrelia burgdorferi has become a major worldwide epidemic.
Stricker RB, Johnson L
doaj
Rapid Targeted Method of Detecting Abused Piperazine Designer Drugs [PDF]
, 2021 Anna Welz +3 more
openalex +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
2C or not 2C: phenethylamine designer drug review. [PDF]
J Med Toxicol, 2013 Dean BV +3 more
europepmc +1 more source
Comparison of LC-MS and LC-DAD Methods of Detecting Abused Piperazine Designer Drugs [PDF]
, 2022 Anna Welz +3 more
openalex +1 more source
Determination of designer drug cross-reactivity on five commercial immunoassay screening kits.
Journal of Analytical Toxicology, 2015 Laura E Regester +5 more
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Isomeric Analysis of Synthetic Cannabinoids Detected as Designer Drugs
, 2011 Nahoko Uchiyama +4 more
openalex +2 more sources