Results 231 to 240 of about 121,553 (350)

1,2-diphenylethylamine designer drugs metabolism studies and toxicological analysis using gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry coupled to low and high resolution-mass spectrometry

, 2016
Carina S. D. Wink
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Designer Receptors Exclusively Activated by Designer Drugs Approach to Treatment of Sleep-disordered Breathing

, 2020
Thomaz Fleury Curado, Huy Pho, Carla Freire, Mateus R. Amorim, Jordi Bonaventura, Lenise Jihe Kim, Rachel Lee, Meaghan E Cabassa, Stone R. Streeter, Luiz G.S. Branco, Luiz Ubirajara Sennes, Kenneth W. Fishbein, Richard G. Spencer, Alan R. Schwartz, Michael J. Brennick, Michel Michaelides, David D. Fuller, Vsevolod Y. Polotsky   +17 more
openalex   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Forensic toxicology of benzodiazepines: neuropharmacological effects, analytical challenges, and emerging detection strategies. [PDF]

Front Toxicol
Irfan Thalib H, Damanhory AA, Hanin Shaikh A, Haidar S, Khan S, Jamal A, Abdelghany OA.   +6 more
europepmc   +1 more source

Precursor discrimination of designer drug benzylpiperazine using delta13C and delta15N stable isotopes

, 2012
Nikkie Michelle Beckett, Sarah L. Cresswell, I. Darren Grice   +2 more
openalex   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Simplifying the problem: metal salts can be active and controlled catalysts in polyester synthesis. [PDF]

Chem Sci
Cheng-Tan MDCL, Wood ZA, Fieser ME.
europepmc   +1 more source

What Difference Does Digital Make? [PDF]

Nadin, Mihai
core  

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source