Results 251 to 260 of about 4,227,388 (391)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Multiple fatalities involving a new designer drug: para-methyl-4-methylaminorex.

Journal of Analytical Toxicology, 2014
S. Cosbey, S. Kirk, M. McNaul, L. Peters, B. Prentice, A. Quinn, S. Elliott, S. Brandt, R. Archer   +8 more
semanticscholar   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Electrochemical Simulation of 25B-NBOMe Phase I Metabolism and Metabolite Profiling by HPLC-QTOF-MS. [PDF]

Molecules
Kot-Wasik A, Potęga A, Aszyk-Woźniak J, Garwolińska D, Wiergowski M, Wasik A.   +5 more
europepmc   +1 more source

Are Designer Drugs Putting Your Heart at Risk? A Comparative Study of Methylone and 3,4-DMMC

Maria Moreira, Verónica Rocha, Ana Margarida Araújo, Márcia Carvalho   +3 more
openalex   +1 more source

Knowledge, attitudes, and perceptions of medical students towards designer drugs in Cairo university: a cross-sectional study [PDF]

Ayham R. Sara, Abla Abdalmeguid Attia, Mai Ahmed Mohammed, Saif E. Alrabadi, Bassam Essam, Amro A. M. Albatrawi, Warda A. Alrubasy, Shams Khalid Sameer, Ahmad J. Taha, Mohammad T. Abuawwad, Mohammad J. J. Taha   +10 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Sex-dependent modulation of behavioral allocation via ventral tegmental area-nucleus accumbens shell circuitry. [PDF]

NeuroImmune Pharm Ther
McLaurin KA, Illenberger JM, Li H, Booze RM, Mactutus CF.   +4 more
europepmc   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

What Difference Does Digital Make? [PDF]

Nadin, Mihai
core