Results 261 to 270 of about 4,227,388 (391)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

A combined pseudouridine biomanufacturing platform enabled by a streamlined designer pathway. [PDF]

Nat Commun
Yu L, Chen R, Zhang C, Wang Z, Wang Z, Zeng X, Liang H, He Y, She Y, Wang Y, Gong R, Song X, Deng Z, Fei Q, Chen W.   +14 more
europepmc   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Optimization of accelerated life test design process for gears and bearings using equivalent damage method. [PDF]

Sci Rep
Kim JH, Kim BS, Park JH, Moon DJ, Kim S, Park YJ.   +5 more
europepmc   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

New psychoactive substances in roadway crash victims in California. [PDF]

Front Toxicol
Gerona R, Tomer D, Nielsen D, Sage AC, French D, Tolles J, Chenoweth JA.   +6 more
europepmc   +1 more source

Metabolite profiling of RCS-4, a novel synthetic cannabinoid designer drug, using human hepatocyte metabolism and TOF-MS. [PDF]

Bioanalysis, 2014
Gandhi AS, Zhu M, Pang S, Wohlfarth A, Scheidweiler KB, Huestis MA.   +5 more
europepmc   +1 more source

Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs

, 2019
Yun‐Rak Choi, Kelsey H. Collins, Jin Woo Lee, Ho Jung Kang, Farshid Guilak   +4 more
openalex   +2 more sources

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

The Role of the Posterior Paraventricular Nucleus of the Thalamus in Food Deprivation-Induced Heroin-Seeking Relapse, in Male and Female Rats. [PDF]

Addict Biol
Borges C, Darecka A, Mainville-Berthiaume A, Ah-Yen E, Darvishmolla M, Courtemanche R, Shalev U.   +6 more
europepmc   +1 more source