Results 21 to 30 of about 4,227,388 (391)

Repeated Exposure to the “Spice” Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats

open access: yesFrontiers in Psychiatry, 2018
Naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) is a synthetic compound found in psychoactive “spice” products that activates cannabinoid receptors.
Joshua S. Elmore, Michael H. Baumann
doaj   +1 more source

Identification of New Designer Benzodiazepine Diclazepam in Drug Facilitated Sexual Assault [PDF]

open access: yesFayixue Zazhi, 2018
Objective To identify the new designer drugs which are totally unknown and not in the routine testing list by the technologies such as high-resolution mass spectrometry in drug facilitated sexual assault, in order to solve the problem in actual cases ...
XIANG Ping, SHEN Bao-hua, YAN Hui, et al
doaj   +1 more source

Human spinal GABA neurons alleviate spasticity and improve locomotion in rats with spinal cord injury

open access: yesCell Reports, 2021
Summary: Spinal cord injury (SCI) often results in spasticity. There is currently no effective therapy for spasticity. Here, we describe a method to efficiently differentiate human pluripotent stem cells from spinal GABA neurons.
ChenZi Gong   +17 more
doaj   +1 more source

Tools for Controlling Activity of Neural Circuits Can Boost Gastrointestinal Research [PDF]

open access: yes, 2016
We thank Prof U. G. Knaus and T. C. Collin for critical reading of the manuscript. GA is supported by the European Crohn's and Colitis Organization (ECCO) (J/15/2) and by the National Childrens' Research Centre (K/12/1). GD is supported by the University
Aviello, Gabriella, D'Agostino, Giuseppe
core   +3 more sources

Recreational use, analysis and toxicity of tryptamines [PDF]

open access: yes, 2015
The definition New psychoactive substances (NPS) refers to emerging drugs whose chemical structures are similar to other psychoactive compounds but not identical, representing a "legal" alternative to internationally controlled drugs.
Mannocchi, Giulio   +3 more
core   +1 more source

Monitoring risk behaviour in adolescent pupils regarding consumption of psychoactive substances

open access: yesAnnals of Agricultural and Environmental Medicine, 2017
Introduction Taking psychoactive substances constitutes a significant problem for Public Health, particularly in preventing drug abuse and addiction. Objectives To estimate the amount and incidence of drug consumption in middle and high school pupils ...
Paulina Wojtyła-Buciora   +8 more
doaj   +1 more source

Thalamic inputs to dorsomedial striatum are involved in inhibitory control: evidence from the five-choice serial reaction time task in rats [PDF]

open access: yes, 2017
Rationale Corticostriatal circuits are widely implicated in the top-down control of attention including inhibitory control and behavioural flexibility. However, recent neurophysiological evidence also suggests a role for thalamic inputs to striatum in
A Bari   +36 more
core   +2 more sources

Grafted hPSC-derived GABA-ergic interneurons regulate seizures and specific cognitive function in temporal lobe epilepsy

open access: yesnpj Regenerative Medicine, 2022
Interneuron loss/dysfunction contributes to spontaneous recurrent seizures (SRS) in chronic temporal lobe epilepsy (TLE), and interneuron grafting into the epileptic hippocampus reduces SRS and improves cognitive function. This study investigated whether
Dinesh Upadhya   +8 more
doaj   +1 more source

Designer antiandrogens join the race against drug resistance

open access: yeseLife, 2013
By using in silico models of the complexes formed by analogues of a cancer drug and its receptor, it may be possible to strategically redesign existing drugs and win the race against mutations that lead to drug resistance in prostate cancer.
Jatinder S Josan   +1 more
doaj   +1 more source

Methamphetamine and Designer Stimulants Modulate Tonic Human Cerebrovascular Smooth Muscle Contractility: Relevance to Drug-Induced Neurovascular Stress

open access: yesPathophysiology, 2023
To avoid criminal prosecution, clandestine chemists produce designer stimulants that mimic the pharmacological and psychoactive effects of conventional stimulants, such as methamphetamine.
Nicole Hall   +9 more
doaj   +1 more source

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