Results 291 to 300 of about 4,227,388 (391)

Involvement of KEAP1/NRF2 pathway in non-BRAF mutated squamous cell carcinoma of the thyroid. [PDF]

J Pathol
Schoultz E, Dahlberg J, Nilsson LM, Dzanan JJ, Carlsson T, Dahr N, Andersson E, Muhammad G, Muth A, Elias E, Fagman H, Sayin VI, Nilsson JA, Nilsson M.   +13 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Lateral habenula-rostromedial tegmental nucleus circuit mediates inflammatory pain in mice. [PDF]

J Headache Pain
Sun Y, Cao J, Xu C, Sun J, Liu X, Shi Z, An S, Zhao D, Sun D, Wang X, Zhao G, Zhang C, Li G, Xiao J, Yang J, Zhao H.   +15 more
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

DREADDs-Based Chemogenetics Induced Slow Transit Constipation via Inhibition of Enteric Neurons. [PDF]

J Dig Dis
Lu XY, Wen YX, Jiang N, Zhou SQ, Yang T, Shi LL, Guo HM, Zhang W, Zhang QP, Zhang NN.   +9 more
europepmc   +1 more source

Polydrug fatal intoxication involving MDPHP: Detection and in silico investigation of multiple 3,4-methylenedioxy-derived designer drugs and their metabolites. [PDF]

J Anal Toxicol
Casati S, Ravelli A, Dei Cas M, Bergamaschi RF, Vanerio S, Sicuro L, Faraone C, Rossi M, Galante N, Mollica L, Roda G, Rota P, Battistini A.   +12 more
europepmc   +1 more source