Results 41 to 50 of about 4,227,388 (391)

A frame signature matrix for analysing and comparing interaction design behaviour [PDF]

, 2012
Protocol studies are an established method to investigate design behaviour. In the context of a project to investigate novice interaction design (ID) behaviour across protocols and cultures, we found that existing design behaviour analysis frameworks did
Blyth, Richard, Rajah, Dino, Schadewitz, Nicole, Sharp, Helen, Turugare, Ranganai, Woodroffe, Mark   +5 more
core   +1 more source

“Being with a Buddha”: A Case Report of Methoxetamine Use in a United States Veteran with PTSD

Case Reports in Psychiatry, 2017
Methoxetamine (MXE) is a ketamine analogue with a high affinity for the N-methyl-D-aspartate (NMDA) receptor. MXE is a newly emerging designer drug of abuse and is widely available through on-line sources and is not detected by routine urine drug screens.
Joan M. Striebel, Emily E. Nelson, Raj K. Kalapatapu   +2 more
doaj   +1 more source

Oneiroid catatonia due to the usage of spice: The case study

European Psychiatry, 2021
Introduction Designer drugs, as a term, first came about in the 1980s. Most of these “designer drugs” have synthetic cannabinoids and other psychoactive formulas difficulty to detect. Objectives A 28 year man was referred to the hospital.
O. Pityk, A. Pushko, N. Striltsiv, O. Lutska, N. Karbovskyi   +4 more
doaj   +1 more source

Designer DNA-silica/carbon nanotube nanocomposites for traceable and targeted drug delivery.

Journal of materials chemistry. B, 2020
Due to their unique properties like porosity, high water content, softness and biocompatibility, hydrogels are of great interest for biomedical applications such as tissue engineering and drug delivery.
Yong Hu, C. Niemeyer
semanticscholar   +1 more source

Rational Drug Design Paradigms: The Odyssey for Designing Better Drugs

Combinatorial Chemistry & High Throughput Screening, 2015
Due to the time and effort requirements for the development of a new drug, and the high attrition rates associated with this developmental process, there is an intense effort by academic and industrial researchers to find novel ways for more effective drug development schemes.
Kellici T, Ntountaniotis D, Vrontaki E, Liapakis G, MoutevelisMinakakis P, Kokotos G, Hadjikakou S, Tzakos AG, Afantitis A, Melagraki G, Bryant S, Langer T, Di Marzo V, Mavromoustakos T   +13 more
openaire   +4 more sources

Designer Drugs: A Review of Literature Abdulsallam Bakdash

Arab Journal of Forensic Sciences & Forensic Medicine, 2015
A new phenomenon in the drug market has appeared in recent years: there has been an increase in the number and types of designer drugs. A massive influx of these structural and/or functional analogs of controlled substances has resulted in an increase in
Abdulsallam Bakdash
doaj   +1 more source

The bridge between classical and ‘synthetic’/chemical psychoses: towards a clinical, psychopathological and therapeutic perspective [PDF]

, 2019
© 2019 Orsolini, Chiappini, Papanti, De Berardis, Corkery and Schifano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Chiappini, Stephania, Corkery, John Martin, De Berardis, Domenico, Orsolini, Laura, Papanti, Duccio, Schifano, Fabrizio   +5 more
core   +2 more sources

Designer cellular spheroids with DNA origami for drug screening

Science Advances
Current in vitro models struggle to balance the complexity of human diseases with suitability for large-scale drug tests. While 3D cultures simulate human tissues, they lack cellular intricacy, and integrating these models with high-throughput drug ...
Jiayi Wei, Yueyang Sun, Heming Wang, Tong Zhu, Li Li, Ying Zhou, Quan Liu, Zhen Dai, Wenjuan Li, Taihua Yang, Bingmei Wang, Changfeng Zhu, Xizhong Shen, Qunyan Yao, Guangqi Song, Yicheng Zhao, Hao Pei   +16 more
semanticscholar   +1 more source

Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice

Pharmacological Research
2-Benzylbenzimidazole derivatives or ‘nitazenes’ are increasingly present on the recreational drug market. Here, we report the synthesis and pharmacological characterization of 15 structurally diverse nitazenes that might be predicted to emerge or grow ...
Marthe M. Vandeputte, Grant C. Glatfelter, Donna Walther, Nathan K. Layle, Danielle M. St. Germaine, István Ujváry, Donna M. Iula, Michael H. Baumann, Christophe P. Stove   +8 more
doaj   +1 more source

Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes [PDF]

, 2018
The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating ...
Bradley, Sophie J., Broad, Lisa M., Brooke, Simon M., Bundgaard, Christoffer, Christopoulos, Arthur, Crabtree, Michael D., Dwomoh, Louis, Felder, Christian C., Langmead, Christopher J., Mogg, Adrian J., Molloy, Colin, Sanger, Helen E., Sexton, Patrick M., Thompson, Karen J., Tobin, Andrew B.   +14 more
core   +1 more source