Results 271 to 280 of about 94,066 (344)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Assembling a Difficult Airway Cart/Kit, declaring "Code D", and issuing an Airway Alert Card for unanticipated difficult airway management proposed by the All India Difficult Airway Association. [PDF]

Indian J Anaesth
Garg R, Ahmed SM, Myatra SN, Shah AP, Ramkumar V, Patwa A, Shetty SR, Divatia JV, Doctor JR, Kundra P.   +9 more
europepmc   +1 more source

Safety and Cognitive Pharmacodynamics Following Dose Escalations with 3-Methylmethcathinone (3-MMC): A First in Human, Designer Drug Study

J. Reckweg, J. Ramaekers, N. Mason, K. Kuypers, S. Toennes, E. Theunissen   +5 more
openalex   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Fear and Fashion in the Cold War [PDF]

, 2008
Pavitt, Jane
core  

Electrochemical Simulation of 25B-NBOMe Phase I Metabolism and Metabolite Profiling by HPLC-QTOF-MS. [PDF]

Molecules
Kot-Wasik A, Potęga A, Aszyk-Woźniak J, Garwolińska D, Wiergowski M, Wasik A.   +5 more
europepmc   +1 more source

Sex-dependent modulation of behavioral allocation via ventral tegmental area-nucleus accumbens shell circuitry. [PDF]

NeuroImmune Pharm Ther
McLaurin KA, Illenberger JM, Li H, Booze RM, Mactutus CF.   +4 more
europepmc   +1 more source

A cytokine-based designer enzyme with an abiological multinuclear metal center exhibits intrinsic and extrinsic catalysis. [PDF]

Nat Commun
Ueno A, Takida F, Kita T, Ishii T, Himiyama T, Mabuchi T, Okamoto Y.   +6 more
europepmc   +1 more source