Results 31 to 40 of about 438,483 (295)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

Transcendent Philosophy, Na’eeni School, and Muhammad Taghi Ja’fari on Free will and Necessity [PDF]

open access: yesپژوهشنامه فلسفه دین, 2014
The relation between free will and necessity is one of the most important issues regarding the problem of “free will”. This is because of the rule which indicates that “being not necessary, an event would not be came off”.
abdollah nasri
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Belonging and Longing: The Question of the Subject in Renaud Barbaras and Jean-Luc Marion

open access: yesText Matters
The philosophy of Renaud Barbaras and Jean-Luc Marion departs from the transcendental role of the subject. No longer is the subject regarded as its own foundation, nor does it own or constitute its objects.
Szczepan Urbaniak
doaj   +1 more source

Violencia y cuerpo agotado en la Segunda Parte de Don Quijote de la Mancha

open access: yesCriticón, 2020
The present study dwells on the various forms of physical violence in the second part of the Don Quixote de la Mancha, in connection with the theme of bodily decay.
Philippe Rabaté
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

open access: yesFEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani   +4 more
wiley   +1 more source

Hooked on an Affect: Detroit Techno and Dystopian Digital Culture

open access: yesDancecult: Journal of Electronic Dance Music Culture, 2011
Detroit techno is typically historicized as having grown out of the late 1970s and early 1980s middle-class, consumerist, and aspirational high school social party scene, giving the impression that Detroit techno artists created forward-thinking music as
Richard Pope
doaj  

The changing career of luxury: From moral threat to material well-being

open access: yesResearch in Hospitality Management, 2021
The elusive nature of luxury and its history have been discussed for thousands of years. Previously known to be for the rich and famous, it could be argued that luxury is a moral threat to society, bringing about social divides and tension.
Christopher J. Berry
doaj   +1 more source

Newly Desiring and Desired

open access: yesM/C Journal, 1999
"... sphincters have no souls."-- Germaine Greer. "Love." The Whole Woman. 222. "Place your hands on my (w?)hole, run your fingers through my soul..." -- Gary Stringer. "Place Your Hands." Glow. A remarkable pseudo-sodomitical sight gag in the Hollywood comedy film Austin Powers: The Spy Who ...
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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