Results 51 to 60 of about 851,141 (296)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
A Parody of Love: the Narrative Uses of Rape in Popular Romance
Journal of Popular Romance Studies, 2012 Discussions of rape in popular romance have most often centered on how these scenes affect or reflect the lives of romance readers. Detractors of the genre have used its presence to support the notion that romance is a patriarchal and repressive literary
Angela R. Toscano
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Job Desire and Motivation: Response Distortion in Personality Assessment [PDF]
, 2014 This study examined personality response distortion based on an individual‟s job desire within a personnel selection scenario. The aim was to determine the extent to which job desire affected individuals‟ responses to a personality assessment.
Roess, Michaella Delphine
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Fertility Desire and Intention of People Living with HIV/AIDS in Tanzania: A call for Restructuring Care and Treatment Services. [PDF]
, 2013 Scaling up of antiretroviral therapy (ART) is currently underway in sub-Saharan Africa including, Tanzania, increasing survival of people living with HIV/AIDS (PLWHA). Programmes pay little attention to PLWHA's reproductive health needs.
Mmbaga Elia J +17 more
core +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Women's Sexual Desire: Challenging Narratives of "Dysfunction" [PDF]
, 2017 Recent changes in the classification of female sexual dysfunction in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM) and the US Food and Drug Administration’s (FDA) approval of the first drug to treat low sexual
Cynthia A. Graham +5 more
core +1 more source
Queering diasporic decolonial feminisms on, against and beyond borders
Relaciones InternacionalesIn this queering decolonial feminist co(w)riting we bring to text a plural voice making of the philosophies and dark wisdoms emergent when queer decolonial feminist diasporic migrant/refugee (non)subjects speak in their/our own terms.
Sara Motta, Suman Lahiry
doaj +1 more source