Results 51 to 60 of about 402,644 (264)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
A Parody of Love: the Narrative Uses of Rape in Popular Romance
Journal of Popular Romance Studies, 2012 Discussions of rape in popular romance have most often centered on how these scenes affect or reflect the lives of romance readers. Detractors of the genre have used its presence to support the notion that romance is a patriarchal and repressive literary
Angela R. Toscano
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Pro-Posições, 2009 Nosso engajamento com o filme Tropa de elite, de 2007, do diretor José Padilha, é pertinente a discussões mais amplas acerca do papel do desejo e da lei nas formações de geografias do lugar.
James Craine, Giorgio Hadi Curti
doaj +1 more source
Macroeconomic Dynamics, 2016 This paper explores the impact of gender differences in the desire for sex and the distribution of power in the household on the onset of the demographic transition and the take-off to growth. Depending on the price and efficacy of modern contraceptives, the gender wage gap, and female bargaining power, the economy assumes one of two possible ...
openaire +4 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Queering diasporic decolonial feminisms on, against and beyond borders
Relaciones InternacionalesIn this queering decolonial feminist co(w)riting we bring to text a plural voice making of the philosophies and dark wisdoms emergent when queer decolonial feminist diasporic migrant/refugee (non)subjects speak in their/our own terms.
Sara Motta, Suman Lahiry
doaj +1 more source