Results 71 to 80 of about 3,096,255 (309)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Queering diasporic decolonial feminisms on, against and beyond borders

open access: yesRelaciones Internacionales
In this queering decolonial feminist co(w)riting we bring to text a plural voice making of the philosophies and dark wisdoms emergent when queer decolonial feminist diasporic migrant/refugee (non)subjects speak in their/our own terms.
Sara Motta, Suman Lahiry
doaj   +1 more source

Introduction. Reconsidering Some Dogmas About Desire [PDF]

open access: yes, 2017
Desire has not been at the center of recent preoccupations in the philosophy of mind. Consequently, the literature settled into several dogmas. The first part of this introduction presents these dogmas and invites readers to scrutinize them.
Deonna, Julien, Lauria, Federico
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Working Paper 93 - The Impact of High Oil Prices on African Economies [PDF]

open access: yes
On the one hand the high price of oil is a unique opportunity for African oil producers to use the windfall gains to speed up their development. On the other hand, it is having adverse effects on net-oil importing countries, in particular those which ...
Abdul Kamara   +1 more
core  

DESIRE AND DEVELOPMENT

open access: yesMacroeconomic Dynamics, 2016
This paper explores the impact of gender differences in the desire for sex and the distribution of power in the household on the onset of the demographic transition and the take-off to growth. Depending on the price and efficacy of modern contraceptives, the gender wage gap, and female bargaining power, the economy assumes one of two possible ...
openaire   +4 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Vrais Amis: Reconsidering the Philosophical Relationship Between Foucault and Deleuze

open access: yesFoucault Studies, 2018
In the current literature addressing the Foucault/Deleuze relationship, there is a clear tendency to either replicate and expand Foucault’s over-simplified rejection of Deleuzian desire as already caught in a discursive trap or play of power; or to ...
Christian Gilliam
doaj   +1 more source

A pilot investigation into the effect of maca supplementation on physical activity and sexual desire in sportsmen [PDF]

open access: yes, 2009
AIMS OF THE STUDY: Maca (Lepidium meyenii Walp) is consumed both as a sports supplement by strength and endurance athletes, and as a natural stimulant to enhance sexual drive.
Alvin Ibarra   +18 more
core   +2 more sources

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