Results 81 to 90 of about 3,096,255 (309)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Analysis of Emotion, Habit,and Rational Choice: A Study on Consumer Behavior

open access: yesInternational Research Journal of Business Studies, 2011
Along with the process of globalization, the retail industry has been growing into a business that is very influential in the world economy, including Indonesian economy.
Christina Whidya Utami
doaj   +3 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

The Ohio Company and the Meaning of Opportunity in the American West 1786-1795

open access: yes, 1991
Founded in 1786 by former officers of the Continental Army to promote an orderly expansion of American society westward, the Ohio Company soon succumbed to the desire of many of its investors to make money.
Shannon, Timothy J.
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Hegel’s Phenomenology: On the Logical Structure of Human Experience

open access: yesOpen Philosophy, 2019
I argue that Hegel’s Phenomenology is an attempt to prove that human experience displays a sui generis logical structure. This is because, as rational animals who instinctively create a universe of meaning to navigate our environment, the perceptual ...
Carew Joseph
doaj   +1 more source

Bodily Signs and Disembodied Narrative in Pamela II [PDF]

open access: yes, 2017
To a large extent, the detractors of Pamela criticized Richardson’s focus on the body. Pamela’s actions and narrative style appeared to be motivated by her desire, namely, by her passions, traditionally located in the body. In particular, Pamela’s bodily
Capoferro, Riccardo
core   +3 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Inorganic arrangement crystal beryllium, lithium, selenium and silicon

open access: yes, 2015
The use of inorganic crystals technology has been widely date. Since quartz crystals for watches in the nineteenth century, and common way radio in the early twentieth century, to computer chips with new semiconductor materials. Chemical elements such as
Fedrigo, Desire Francine Gobato   +2 more
core  

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