Results 81 to 90 of about 403,574 (263)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

La palabra inhabitable: Sarah Klassen y Simone Weil / Uninhabitable Words: Sarah Klassen and Simone Weil

open access: yesAsparkía, 2007
RESUMEN: Este artículo analiza el sexto libro de la poeta canadiense Sarah Klassen, Simone Weil: Songs of Hunger and Love (1999), una colección de poemas y breves piezas en prosa donde la autora presta su primera persona a Simone Weil, filósofa francesa ...
Nieves Pascual Soler
doaj  

Newly Desiring and Desired

open access: yesM/C Journal, 1999
"... sphincters have no souls."-- Germaine Greer. "Love." The Whole Woman. 222. "Place your hands on my (w?)hole, run your fingers through my soul..." -- Gary Stringer. "Place Your Hands." Glow. A remarkable pseudo-sodomitical sight gag in the Hollywood comedy film Austin Powers: The Spy Who ...
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

THE CITY AND THE RESURFACING OF THE REPRESSED. SPACE IN THE NOVEL U REGISTRATURI BY ANTE KOVAČIĆ

open access: yesFluminensia: Journal for Philological Research, 2009
Together with the decline of the nobility, the city schooling of a country child and the twofold village-city relationship are the key themes of Croatian realism, as well as realism world-wide.
Dejan Durić
doaj  

Revisión de la teología agustiniana con una original teoría sobre el deseo. (Primera parte) / Reviewing Augustinian Theology by an original theory of desire. (Part 1)) [PDF]

open access: yesComunicación y Hombre, 2010
La tradición cristiana se fundamenta sobre tres pilares: el pecado original, el Mediador, y el sacrificio, que sustentan una filosofía de la historia. San Agustín es uno de los exponentes de este esquema, pero necesita un lenguaje actualizado, frente a ...
Ángel Jorge Barahona Plaza
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy