Results 151 to 160 of about 7,754 (200)

Disposition of Desloratadine in Healthy Volunteers

Xenobiotica, 2007
The absorption, metabolism and excretion of desloratadine (DL, Clarinex) were characterized in six healthy male volunteers. Subjects received a single oral 10-mg dose of [(14)C]DL ( approximately 104 microCi). Blood, urine and feces were collected over 240 h.
Swapan K Chowdhury, A -D Su
exaly   +3 more sources

Prevalence of Desloratadine Slow-Metabolizer Phenotype and Food-Dependent Pharmacokinetics of Desloratadine in Healthy Chinese Volunteers

Clinical Drug Investigation, 2015
Desloratadine, the major active metabolite of loratadine, is a non-sedating long-acting antihistamine that is widely used in the treatment of allergic rhinitis and chronic idiopathic urticaria. This study aimed to investigate the prevalence of desloratadine slow-metabolizer (DSM) phenotype and the effects of food on the pharmacokinetics of ...
Xuehua Jiang, Ting Wang, Ling Wang
exaly   +3 more sources

Desloratadine Prevents Compound 48/80-Induced Mast Cell Degranulation: Visualization Using a Vital Fluorescent Dye Technique

Allergy: European Journal of Allergy and Clinical Immunology, 2005
peer reviewedBACKGROUND: Desloratadine is a selective H1-antihistamine used in the treatment of allergic rhinitis and chronic idiopathic urticaria. Desloratadine inhibits the release of allergic inflammatory mediators in vitro.
Adrian F. Daly, William Kreutner, J Y Wei   +2 more
exaly   +2 more sources

Acid–Base Equilibria and Solubility of Loratadine and Desloratadine in Water and Micellar Media

Journal of Pharmaceutical and Biomedical Analysis, 2009
Acid-base equilibria in homogeneous and heterogeneous systems of two antihistaminics, loratadine and desloratadine were studied spectrophotometrically in Britton-Robinson's buffer at 25 degrees C. Acidity constant of loratadine was found to be pK(a) 5.25
Danica Agbaba, Gordana Popovic
exaly   +2 more sources

Desloratadine: A Nonsedating Antihistamine

The Annals of Pharmacotherapy, 2003
OBJECTIVE: To review information on desloratadine, a nonsedating antihistamine. DATA SOURCES: An English-language MEDLINE search was conducted (1966–July 2002).
Lynn, Limon, Denise R, Kockler
openaire   +2 more sources

Desloratadine: A preclinical and clinical overview

Drugs of Today, 2001
A new competitive histamine H(1)-receptor antagonist with superior binding affinity at this receptor as compared with other common antihistamines, desloratadine is the active metabolite of loratadine, the most extensively used agent of this class. Under development for the treatment of allergic rhinitis and urticaria and currently awaiting regulatory ...
P., Norman, A., Dihlmann, X., Rabasseda
openaire   +2 more sources

Desloratadine

Drugs, 2003
Desloratadine (Clarinex, Neoclarityn, Aerius, Azomyr, Opulis, Allex), the principal metabolite of loratadine, is itself an orally active, nonsedating, peripheral histamine H(1)-receptor antagonist. It is indicated in the US and Europe for the treatment of seasonal allergic rhinitis (SAR), perennial allergic rhinitis (PAR) and chronic idiopathic ...
David, Murdoch, Karen L, Goa, Susan J, Keam   +2 more
openaire   +2 more sources

Pharmacology of Desloratadine

Clinical Drug Investigation, 2002
Desloratadine is a new, nonsedating H1 receptor antagonist, which has been shown to have good tolerability and to be effective in the treatment of seasonal allergic rhinitis, perennial allergic rhinitis and chronic idiopathic urticaria. The pharmacological profile of desloratadine exhibits particular advantages compared with other antihistamines in ...
openaire   +1 more source

Safety evaluation of desloratadine in allergic rhinitis

Expert Opinion on Drug Safety, 2013
Desloratadine is a biologically active metabolite of second-generation antihistamine loratadine. It is also indicated for the treatment of allergic diseases, including allergic rhinitis.A Medline search was conducted to identify preclinical and clinical studies of desloratadine.
Vanesa, González-Núñez, Antonio, Valero, Joaquim, Mullol   +2 more
openaire   +2 more sources

Desloratadine: A new, nonsedating, oral antihistamine

Journal of Allergy and Clinical Immunology, 2001
Desloratadine is a new, selective, H(1)-receptor antagonist that also has anti-inflammatory activity. In vitro studies have shown that desloratadine inhibits the release or generation of multiple inflammatory mediators, including IL-4, IL-6, IL-8, IL-13, PGD(2), leukotriene C(4), tryptase, histamine, and the TNF-alpha-induced chemokine RANTES ...
R S, Geha, E O, Meltzer
openaire   +2 more sources