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Anti‐inflammatory properties of desloratadine
Clinical & Experimental Allergy, 2004SummaryBackground Allergic rhinitis (AR) is associated with robust infiltration of immune cells and mediators that may contribute to clinical manifestations of the disease.Objective To review the complex immune effector mechanisms involved in the allergic response and discuss their effects on the pathophysiological and clinical ...
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Desloratadine in the treatment of chronic idiopathic urticaria
Allergy, 2001Chronic idiopathic urticaria (CIU) is a common dermatologic disorder that may severely impair quality of life. Patients may suffer symptoms such as pruritus and disfigurement due to wheals for years or decades. Advances have been made in the last 10 years with the identification of an autoimmune pathogenesis in a significant proportion of patients ...
J, Ring, R, Hein, A, Gauger
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Oral Bioavailability of Desloratadine Is Unaffected by Food
Clinical Pharmacokinetics, 2002To determine the effect of coadministration of food on the bioavailability of oral desloratadine.A randomised, open-label, single dose crossover study in which healthy adults received a single, oral dose of desloratadine 7.5mg, 50% greater than the recommended dose of 5mg, under fed or fasted conditions and were then crossed over to receive the other ...
Samir, Gupta +5 more
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Form I of desloratadine, a tricyclic antihistamine
Acta Crystallographica Section C Crystal Structure Communications, 2006The title compound [systematic name: 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[4,5]cyclohepta[2,1-b]pyridine], C19H19ClN2, was crystallized from ethyl acetate. The interesting feature of the reported structure is that it does not contain any strong hydrogen bonds, although the molecule contains a secondary NH group, which is a good ...
Prashant M, Bhatt, Gautam R, Desiraju
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