Results 111 to 120 of about 43,204 (229)

Dual Color Photoactivation Localization Microscopy of Cardiomyopathy-associated Desmin Mutants

, 2012
Brodehl A, Hedde PN, Dieding M, et al. Dual Color Photoactivation Localization Microscopy of Cardiomyopathy-associated Desmin Mutants. Journal of Biological Chemistry.
Fatima, A., Heilemann, M., Gayda, S., Walhorn, Volker ; https://orcid.org/, Fatima, Azra, Klauke, B., Gummert, J., Gayda, Susan, Brodehl, Andreas, Nienhaus, Gerd Ulrich, Milting, H., Saric, T., Dieding, Mareike, Gummert, Jan, Saric, Tomo, Klauke, Bärbel, Anselmetti, D., Brodehl, A., Hedde, P. N., Hedde, Per Niklas, Anselmetti, Dario ; https://orcid.org/, Dieding, M., Nienhaus, G. U., Milting, Hendrik, Walhorn, V., Heilemann, Mike   +25 more
core   +1 more source

Cleavage of desmin by cysteine proteases: Calpains and cathepsin B

, 2004
The intermediate filament protein, desmin, was purified from pork longissimus dorsi and incubated with either P-calpain, m-calpain or cathepsin B. Proteolysis of desmin was followed using SDS-PAGE and Western blotting. After incubation of desmin with the
Purslow, P.P., Baron, Caroline, Jacobsen, S.   +2 more
core   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Characterization of cardiac involvement in patients with LMNA splice-site mutation–related dilated cardiomyopathy and sudden cardiac death

Frontiers in Genetics
Introduction:LMNA splicing mutations occur in 9.1% of cases with cardiac involvement cases, but the phenotype and severity of disease they cause have not yet been systematically studied. The aim of this study was to understand the clinical and pathogenic
Xuebin Ling, Yanjun Hou, Xingyu Jia, Youling Lan, Xiaoping Wu, Julan Wu, Wei Jie, Hui Liu, Shan Huang, Zhenling Wan, Tianfa Li, Junli Guo, Tiebiao Liang   +12 more
doaj   +1 more source

Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects

, 2005
Background: Primary desminopathies are caused by desmin gene [DES (MIM*125660)] mutations. The clinical spectrum includes pure myopathies, cardiomuscular diseases and cardiomyopathies.
G. Azan, S. Previtali, L. Tavazzi, PELLEGRINI, CARLO, G. Piccolo, M. Pasotti, O. Bellini, M. Grasso, C. Campana, A. Pilotto, VIGANO', MARIO, A. Repetto, ARBUSTINI, ELOISA, M. Scaffino   +13 more
core   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

Desmoid Fibromatosis of the Gastric Wall Mimicking Needle Tract Seeding after Endoscopic Ultrasound‐Guided Fine‐Needle Biopsy for Pancreatic Cancer: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Endoscopic ultrasound‐guided fine‐needle biopsy (EUS‐FNB) is widely used for the pathological diagnosis of pancreatic diseases. However, needle tract seeding (NTS) remains a clinical concern, particularly when the puncture route is not included in the surgical resection field. We report a case in which distinguishing NTS from other pathologies
Kazuya Koyama, Kenji Takahashi, Hidemasa Kawabata, Yusuke Ono, Nobue Tamamura, Tetsuhiro Okada, Hidetaka Iwamoto, Mishie Tanino, Mikihiro Fujiya, Yusuke Mizukami   +9 more
wiley   +1 more source

Temperature Changes During and after Eccentric Contractions and its Effect on Force and Desmin Loss in Rat

Acta Medica Iranica, 2011
The typical features of eccentric exercise-induced muscle damage is prolonged loss of muscle strength and the most rapid structural change in the fibers is loss of immunostaining for the intermediate filament protein, desmin.
Behnoosh Vasaghi-Gharamaleki, Mansoor Keshavarz, Shahryar Gharibzadeh, Masoud Sotodeh, Hamidreza Marvi, Javad Mosayebnejad, Ismail Ebrahimi Takamjani   +6 more
doaj  

Colonic Perineurioma Presenting as a Small Subepithelial Lesion With Distinctive Endoscopic Findings

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT A 59‐year‐old man with a history of colorectal polypectomy underwent a screening colonoscopy. A 5‐mm reddish lesion was identified in the sigmoid colon. The lesion had a smooth surface without erosion or ulceration and appeared slightly elevated with well‐demarcated margins.
Hironobu Takedomi, Moeko Shirozu, Kayoko Fukuda, Takashi Yao, Motohiro Esaki   +4 more
wiley   +1 more source

Gastric Metastasis of Uterine Leiomyosarcoma Detected During Surveillance Endoscopy and Resected by Endoscopic Submucosal Dissection After Multiple Metachronous Metastases: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Uterine leiomyosarcoma (uLMS) is a rare, aggressive uterine malignancy that usually metastasizes hematogenously, whereas gastrointestinal involvement is uncommon. A 69‐year‐old woman with uLMS treated by hysterectomy and adjuvant chemotherapy developed metachronous lung, sigmoid colon, gallbladder, and abdominal wall metastases.
Yuiko Nagasawa, Takahiro Hiratsuka, Daisuke Minezaki, Wataru Miyoshino, Ryo Ogawa, Tomonori Akagi, Hidefumi Shiroshita, Yoshitake Ueda, Kazuhiro Mizukami, Masafumi Inomata   +9 more
wiley   +1 more source